CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) TIMP-3 Recruits Quiescent Hematopoietic Stem Cells into Active Cell Cycle and Expands Multipotent Progenitor Pool Researchers show that tissue inhibitor of metalloproteinase-3 (TIMP-3), an endogenous regulator of metalloproteinases, stimulates hematopoietic stem cell (HSC) proliferation by recruiting quiescent HSCs into the cell cycle. [Blood] Pre-Transplant Functional Imaging Predicts Outcome Following Autologous Stem Cell Transplant for Relapsed and Refractory Hodgkin Lymphoma Studies evaluating novel salvage therapies, conditioning regimens, post-autologous stem cell transplant (ASCT) maintenance, or allogeneic stem cell transplant are warranted for patients who fail to normalize pre-ASCT functional imaging. [Blood] The Effect of Human Umbilical Cord Blood Cells on Survival and Cytokine Production by Post-Ischemic Astrocytes in Vitro Data demonstrate that the tested cord blood fractions do not enhance astrocyte survival when delivered individually, suggesting there is either another cellular component that is neuroprotective or an interaction of all the cells is essential for protection. [Stem Cell Rev] Availability of Cord Blood Extends Allogeneic Hematopoietic Stem Cell Transplant Access to Racial and Ethnic Minorities Researchers prospectively evaluated availability of unrelated donors and cord blood according to patient ancestry in 553 patients without suitable sibling donors. [Biol Blood Marrow Transplant] Fludarabine Based Conditioning Chemotherapy for Allogeneic Hematopoietic Stem Cell Transplantation in Acquired Severe Aplastic Anemia The Fludarabine-based conditioning regimen used in this study with relatively young cohort of patients was well tolerated with low rate of rejection and treatment outcomes comparable to other more intense and potentially more toxic conditioning regimens. [Biol Blood Marrow Transplant] Characterization of Long-Term Mixed Donor-Donor Chimerism After Double Cord Blood Transplantation Results suggest that the two stable cord blood units are different phenotypically and functionally: one unit shows more naive T cells, lower T cell cytokine production and higher frequencies of natural killer cells, the other shows higher frequencies of well-differentiated and functional lymphocytes. [Clin Exp Immunol] Prognostic Value of Comorbidity for Auto-SCT Eligibility and Outcome in Relapsed or Refractory Aggressive Non-Hodgkin’s Lymphoma In patients with relapsed non-Hodgkin’s lymphoma, comorbidity at relapse is associated with receipt of autologous stem cell transplantation (auto-SCT) and subsequent survival independently from the secondary age-adjusted International Prognostic Index. [Bone Marrow Transplant] Perspectives of Potential Donors on Cord Blood and Cord Blood Cryopreservation: A Survey of Highly Educated, Pregnant Korean Women Receiving Active Prenatal Care A considerable portion of educated pregnant Korean women has more than minimal knowledge of cord blood (CB), but the levels of knowledge regarding the potency of the public bank and the current usefulness and limitations of CB are generally low; in addition, obstetricians play insignificant roles in disseminating knowledge. [Transfusion]
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POLICY NEWS Federal Judge: Obama Stem Cell Policy Halted Research on embryonic stem cells funded by the U.S. government must stop immediately for a court-ordered review, Judge Royce Lamberth of the U.S. District Court for the District of Columbia ruled. [United States District Court for the District of Columbia] NIH Director Collins Says Cell Ruling Won’t Halt Most Ongoing Grants National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States] Universities, Scientists Urge NIH to Narrow Conflicts Rule The biomedical research community is reacting with concern to a proposal from the National Institutes of Health (NIH) to clamp down on financial conflicts of interest in research. [National Institutes of Health, United States] Lawrence A. Tabak Named Principal Deputy Director NIH National Institutes of Health Director Francis S. Collins, M.D., Ph.D., announced the appointment of Lawrence A. Tabak, D.D.S., Ph.D., as principal deputy director of the National Institutes of Health. [National Institutes of Health, United States] Proposed Collection; Comment Request; STAR METRICS–Science and Technology in America’s Reinvestment: Measuring the Effects of Research on Innovation, Competitiveness and Science (FR Doc. 2010-20614) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-20588) [National Institutes of Health, United States] Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20675) [National Institutes of Health, United States] Support of National Institute of General Medical Sciences Program Project Grants (P01) (PAR-10-266) [National Institutes of Health, United States] Submission for Office of Management and Budget Review; Comment Request; Resource for the Collection and Evaluation of Human Tissues and Cells from Donors With an Epidemiology Profile (NCI) (FR Doc. 2010-21098) [National Institutes of Health, United States] National Heart, Lung, and Blood Institute; Notice of Closed Meeting (FR Doc. 2010-20857) [National Institutes of Health, United States] Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]
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EVENTS (Listed by Date) International Society for Cellular Therapy – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010 September 15-17, 2010 Sydney, Australia International Society for Hematology and Stem Cells (ISEH) 2010 Meeting September 15-18, 2010 Melbourne, Australia Cellular Therapy of Cancer Symposium – ATTACK Project Meeting September 24-27, 2010 Montpellier, France International Society for Cell and Gene Therapy of Cancer (ISCGT) Congress September 27-29, 2010 Doha, Qatar 5th Annual Meeting of the German Society for Stem Cell Research September 30-October 2, 2010 Lübeck, Germany AABB (formerly known as the American Association of Blood Banks) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010 October 9-12, 2010 Baltimore, United States Institute for Genomic Medicine Inaugural Symposium October 11-12, 2010 San Diego, United States 5th Annual Translational Stem Cell Research Conference October 12-13, 2010 New York City, United States Fraunhofer Life Science Symposium Leipzig 2010 October 29-30, 2010 Leipzig, Germany BioMalaysia 2010 Conference and Exhibition November 2-4, 2010 Kuala Lumpur, Malaysia World Cord Blood Congress November 4-7, 2010 Marseille, France Cambridge Healthtech Institute’s Inaugural Stem Cells in Drug Discovery and Development November 8-9, 2010 San Diego, United States Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC) November 12-13, 2010 Tianjin, China The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms November 15-18, 2010 Nara, Japan Stem Cell Network’s 10th Annual Scientific Meeting November, 22-24, 2010 Calgary, Alberta 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States Select Biosciences 5th Annual Stem Cells World Congress January 24-25, 2011 San Diego, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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