Cord Blood News Volume 2.39 | Oct 14 2010

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    Cord Blood News 2.39, October 14, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events

    TOP STORY

    Reduced Methyl-CpG Protein Binding Contributing to miR-184 Expression in Umbilical Cord Blood CD4(+) T Cells
    Numerous studies confirm blunted allogeneic responses by umbilical cord blood graft CD4+ T cells. This may be attributable in part to dramatically reduced NFAT1 protein without corresponding mRNA discrepancies. [Leukemia]

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    SCIENCE NEWS

    Research Shows a Promising New Method to Reduce Graft-Versus-Host-Disease After Bone Marrow Transplantation
    Researchers have discovered a new method to prevent the immune-system attacks that often occur following bone marrow transplants. [Press release from the University of Michigan discussing online prepublication in Blood]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    Notch Signaling Is a Critical Regulator of Allogeneic CD4+ T Cell Responses Mediating Graft-Versus-Host Disease
    Results identify Notch as a novel essential regulator of pathogenic CD4+ T cell responses during acute graft-versus-host disease and suggest that Notch signaling in T cells should be investigated as a therapeutic target following allogeneic hematopoietic stem cell transplantation. [Blood]

    Irradiation Enhances the Tumor Tropism and Therapeutic Potential of TRAIL-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Glioma Therapy
    Researchers show that tumor irradiation enhances the tumor tropism of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) and the therapeutic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) delivered by UCB-MSCs. [Stem Cells]

    Human Umbilical Cord Blood Derived Mesenchymal Stem Cells Upregulate Myelin Basic Protein in Shiverer Mice
    Researchers aimed to investigate the potential of human umbilical cord blood-derived pluripotent mesenchymal stem cells to myelinate the axons of shiverer mice brains. [Stem Cells Dev]

    Rituximab Treatment for Epstein Bar Virus (EBV) DNA-Emia, After Alternative Donor Transplants
    The study confirms the effectiveness of rituximab in controlling EBV DNA-emia in allogeneic hemopoietic stem cell transplant; patients with increasing EBV copies despite rituximab, are at high risk of EBV post-transplant lymphoproliferative disorder and may be considered for alternative therapies. [Biol Blood Marrow Transplant]

    Fatal Intracranial Hemorrhage Following Administration of Recombinant Thrombomodulin in a Patient After Cord Blood Transplantation
    Sinusoidal obstruction syndrome (SOS) is a fatal complication after hematopoietic stem cell transplantation. Although the etiology of SOS remains to be fully elucidated, previous studies suggested that preparative regimens cause damage to the sinusoidal endothelial cells leading to a hypercoagulable state and exaggerated cytokine production. [Bone Marrow Transplant]

    Unrelated Umbilical Cord Blood Transplant for Juvenile Metachromatic Leukodystrophy: A Five-Year Follow-Up in Three Affected Siblings
    Unrelated umbilical cord blood transplantation was used to treat three siblings with juvenile metachromatic leukodystrophy. The efficacy of this therapy was measured over a five-year period with serial neurological exams, neuroimaging, nerve conduction studies, and neuropsychological evaluations. [Mol Genet Metab]

    CTD Small Phosphatase Like 2 Can Increase Epsilon- and Gamma-Globin Gene Expression in K562 Cells and CD34+ Cells Derived from Umbilical Cord Blood
    Researchers aimed to identify trans-activators of epsilon- and gamma-globin expression and provide new candidate targets for effective treatment of sickle cell disease and beta-thalassemia through activation of epsilon- and gamma-globin genes in adults. [BMC Cell Biol]

    Immunohistochemical and Transcriptional Expression of Matrix Metalloproteinases in Full-Term Human Umbilical Cord and Human Umbilical Vein Endothelial Cells
    Researchers investigated the expression of matrix metalloproteinases (MMPs) in human umbilical cord and human umbilical vein endothelial cells though immunohistochemistry, RT-PCR and gelatin zymography. [J Mol Histol]


    INDUSTRY NEWS

    American Cancer Society Awards New Research and Training Grants
    The American Cancer Society has awarded 94 national research and training grants totaling $46,633,000 to 70 institutions nationwide in the first of two grants cycles for 2011. [American Cancer Society Press Release]

    BrainStorm Receives Approval to Begin Clinical Trial of Adult Stem Cell Therapy in Patients with ALS
    BrainStorm Cell Therapeutics Inc. announced that the Israeli Ministry of Health has granted clearance for a Phase I/II clinical trial using the company’s autologous NurOwn™ stem cell therapy in patients with amyotrophic lateral sclerosis (ALS). [BrainStorm Cell Therapeutics Inc. Press Release]

    Mesoblast Targets Broader Cancer Indications for Bone Marrow Transplant Product
    Australian regenerative medicine company Mesoblast Limited announced that it is broadening the oncology applications of its “off-the-shelf” cell product for expansion of hematopoietic stem cells in patients with blood cancers. [Mesoblast Limited Press Release]
     
    Mercy Starts First Public Umbilical Cord Blood Program
    Mercy Medical Center announced the state’s first public program allowing parents to donate and bank the stem cells from their newborns’ umbilical cords. [The Baltimore Sun]

    Cryo-Cell International, Inc. Reports Third Quarter 2010 Results
    Cryo-Cell International, Inc. announced results for the third quarter ended August 31, 2010. [Cryo-Cell International, Inc. Press Release]


    POLICY NEWS

    FDA’s $25 Million Pitch for Improving Drug Regulation
    The U.S. Food and Drug Administration (FDA) is pressing for a big funding boost for “regulatory science” — research that can help it evaluate new treatments better and faster. [Food and Drug Administration, United States]

    IQWiG: Law Must Prescribe Obligation to Publish All Clinical Trials
    If the currently discussed draft on the “Law on the Reorganization of the Pharmaceutical Market” (AMNOG) is implemented, drug manufacturers will in future have to register their clinical trials at inception and publish results after completion. [Institute for Quality and Efficiency in Health Care (IQWiG), Germany]

    Advisory Council on Blood Stem Cell Transplantation; Notice of Meeting (FR Doc. 2010-25646) [Department of Health and Human Services, United States]

    Draft Guidance for Industry: Early Clinical Trials With Live Biotherapeutic Products: Chemistry, Manufacturing, and Control Information; Availability (FR Doc. 2010-25850) [Food and Drug Administration, United States]
     
    Draft Guidance for Industry on Investigational New Drug Applications–Determining Whether Human Research Studies Can Be Conducted Without an Investigational New Drug Application; Availability (FR Doc. 2010-25851) [Food and Drug Administration, United States]
     
    Plan to Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting; Request for Comments (FR Doc. 2010-25411) [National Institutes of Health, United States]
     
    Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational Science Awards (CTSA) Initiative (FR Doc. 2010-25589) [Department of Health and Human Services, United States]
     
    Agency Information Collection Request. 30-Day Public Comment Request (FR Doc. 2010-25587) [Department of Health and Human Services, United States]
     
    National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-25634) [National Institutes of Health, United States]
     
    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25595) [National Institutes of Health, United States]
     
    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25597) [National Institutes of Health, United States]
     
    Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25598) [National Institutes of Health, United States]

    Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25601) [National Institutes of Health, United States]
     
    National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-25636) [National Institutes of Health, United States]
     
    National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-25640) [National Institutes of Health, United States]


    EVENTS (Listed by Date)

    National Marrow Donor Program (NMDP) 2010 Council Meeting
    October 15-17, 2010
    Minneapolis, United States

    ‘HAA 2010’ – The Combined Annual Scientific Meeting of HSANZ, ANZSBT AND ASTH
    October 17-20, 2010
    Auckland, New Zealand

    Stem Cells and Regenerative Medicine – New Solutions to Old Problems
    October 18-20, 2010
    San Antonio, United States

    International Consensus Conference: Risk-Based Decision Making for Blood Safety
    October 26-28, 2010
    Toronto, Canada

    2nd Annual Stem Cells Asia and Regenerative Medicine Congress
    October 26-28, 2010
    Seoul, Korea

    Fraunhofer Life Science Symposium Leipzig 2010
    October 29-30, 2010
    Leipzig, Germany

    Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
    November 2-3, 2010
    Singapore

    NEW 2010 National GvHD Symposium
    November 4, 2010
    Cleveland, United States

    World Cord Blood Congress
    November 4-7, 2010
    Marseille, France

    Cambridge Healthtech Institute’s Inaugural Stem Cells in Drug Discovery and Development
    November 8-9, 2010
    San Diego, United States

    Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
    November 12-13, 2010
    Tianjin, China

    The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
    November 15-18, 2010
    Nara, Japan

    Stem Cell Network’s 10th Annual Scientific Meeting
    November 22-24, 2010
    Calgary, Alberta

    52nd American Society of Hematology (ASH) Annual Meeting and Exposition
    December 4-7, 2010
    Orlando, United States

    Select Biosciences 5th Annual Stem Cells World Congress
    January 24-25, 2011
    San Diego, United States

    BMT Tandem Meetings (ASBMT/CIBMTR)
    February 17-21, 2011
    Honolulu, Hawaii

    Molecular Medicine Tri-Conference – Stem Cells: Revolutionizing Regenerative Medicine and Personalized Therapy 2011
    February 23-25, 2011
    San Francisco, United States

    American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
    March 3-6, 2011
    Vancouver, Canada

    Keystone Symposia: Hematopoiesis
    March 27-April 1, 2011
    Big Sky, United States

    American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
    April 2-6, 2011
    Orlando, United States


    Visit
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