Cord Blood News Volume 2.47 | Dec 16 2010

Human Umbilical Cord Blood Cells Found to Enhance Survival and Maturation of Key Brain Cells 
In vitro studies examining the activity of human umbilical cord blood cells (HUCB) on experimental models of central nervous system aging, injury and disease, have shown that HUCBs provide a trophic effect that enhances survival and maturation of hippocampal neurons harvested from both young and old laboratory animals. [Press release from EurekAlert! discussing online prepublication in Aging and Disease]

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Cerebral Palsy Boy Treated with Own Cord Blood Stem Cells
Cryo-Save Group N.V. announced that another sample has been released. A six year old boy from Portugal went to Duke University to participate in a FDA approved clinical trial for cerebral palsy. [Cryo-Save Group N.V. Press Release]

Influence of Infused Cell Dose and HLA-Match on Engraftment After Double-Unit Cord Blood Allografts
Researchers analyzed the impact of cell dose and high-resolution HLA-match on neutrophil engraftment in 84 double-unit cord blood transplant recipients. [Blood]
 
Human and Rhesus Macaque Hematopoietic Stem Cells Cannot Be Purified Based Only Upon SLAM Family Markers
Researchers isolated Signaling Lymphocyte Activation Molecule (SLAM) (CD150+CD48-) and non-SLAM (not CD150+CD48-) cells from human umbilical cord blood CD34+ cells as well as from human and rhesus macaque mobilized peripheral blood CD34+ cells and compared their ability to form colonies in vitro and reconstitute immune-deficient (NOD/SCID/(gamma)c^null, NSG) mice. [Blood]
 
Mesenchymal Stem Cells Secreting Angiopoietin-Like-5 Support Efficient Expansion of Human Hematopoietic Stem Cells Without Compromising Their Repopulating Potential
Researchers report a robust hematopoietic stem cell co-culture system wherein cord blood CD34+ CD133+ cells were co-cultured with mesenchymal stem cells engineered to express angiopoietin like-5 in a defined media. [Stem Cells Dev]
 
The Effect of Obesity on Outcome of Unrelated Cord Blood Transplant in Children with Malignant Diseases
Researchers sought to determine the effect of obesity among 200 children who were prospectively enrolled on a multicenter cord blood transplant trial. [Bone Marrow Transplant]
 
Expansion of CD4(+)CD25(+) Regulatory T Cells from Cord Blood CD4(+) Cells Using the Common Gamma-Chain Cytokines (IL-2 and IL-15) and Rapamycin
Researchers tried to expand CD4(+)CD25(+) regulatory T cells from umbilical cord blood CD4-positive cells using interleukin (IL)-15 or IL-2 with transforming growth factor-beta and rapamycin. [Ann Hematol]
 
Human Umbilical Cord Blood Cells Have Trophic Effects on Young and Aging Hippocampal Neurons In Vitro
The aim of this study was to examine whether the human umbilical cord blood cells produce trophic factors that may enhance survival and maturation of hippocampal neurons in an in vitro test system. [Aging Dis]
 
Are Globoseries Glycosphingolipids SSEA-3 and -4 Markers for Stem Cells Derived from Human Umbilical Cord Blood?
Findings indicate that SSEA-3 and/or -4 may not be optimal markers for multipotency in the case of stem cells derived from cord blood, as their expression may be altered by cell-culture conditions. [J Mol Cell Biol]

China Cord Blood Corporation Announces Completion of Warrant Exchange
China Cord Blood Corporation announced the completion of its previously announced warrant exchange offer, which allowed warrant holders to receive one ordinary share for every eight warrants outstanding. [China Cord Blood Corporation Press Release]

Four Community Independent Blood Centers in Texas Announce the “Alliance for Community Transfusion Services”
Against a background of dynamic change in the health care industry that emphasizes increasing access to medical and surgical treatments while reducing costs, the community independent blood centers in Austin, Corpus Christi, Dallas Fort Worth, and San Antonio have undertaken a collaborative approach as the Alliance for Community Transfusion Services. [South Texas Blood and Tissue Center Press Release]

Cryo-Cell International Responds to Announcement of Intent to Acquire One of the Company’s Global License Affiliates
Cryo-Cell International, Inc. responded to a recent announcement of intent by a prospective acquirer to purchase one of the Company’s global license affiliates, an independent company, for a purported maximum purchase price of $17.84 million. [Cryo-Cell International, Inc. Press Release]

Senate Spending Bill Would Boost NSF, NIH Budgets
In some good fiscal news yesterday for the U.S. science community, a Senate spending panel has crafted a 2011 federal budget that would give several science agencies increases that are close to their requested levels. [Senate, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)
 
Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Inaugural Theranostics for Personalised Medicine
May 18-19, 2011
London, United Kingdom
 
13th Annual C21 BioVentures
May 24-26, 2011
Napa, United States

9th Annual International Umbilical Cord Blood Transplantation Symposium
June 9-11, 2011
San Francisco, United States

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

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