Cord Blood News Volume 3.00 | Jan 6 2011

NRAS^G12D Induces Stepwise Transformation in Preleukemic Human Umbilical Cord Blood Cultures Expressing the AML1-ETO Fusion Gene
Whether constitutively active Ras promotes leukemogenesis on the t(8;21) background has not been demonstrated experimentally. Here, researchers retrovirally expressed NRAS^G12D in AML1-ETO-expressing human hematopoietic cells to investigate cooperativity. [Blood]
 

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How I Treat Late Effects in Adults After Allogeneic Stem Cell Transplantation
The purpose of this paper is to describe practical approaches to screening for and managing the late effects associated with allogeneic hematopoietic stem cell transplantations (allo-HCT), with the goal of reducing preventable morbidity and mortality associated with allo-HCT. [Blood]

Analysis of the Chondrogenic Potential and Secretome of Mesenchymal Stem Cells Derived from Human Umbilical Cord Stroma
Mesenchymal stem cells (MSCs) from umbilical cord stroma were isolated by plastic adherence and characterized by flow cytometry, looking for cells positive for OCT3/4 and SSEA-4 as well as the classic MSC markers CD44, CD73, CD90, Ki67, CD105, and CD106 and negative for CD34 and CD45. [Stem Cells Dev]

Human Umbilical Cord Mesenchymal Stromal Cells in a Sandwich Approach for Osteochondral Tissue Engineering
Human umbilical cord mesenchymal stromal cells, derived from Wharton’s jelly, were introduced to the field of osteochondral tissue engineering and a new strategy for osteochondral integration was developed by sandwiching a layer of cells between chondrogenic and osteogenic constructs before suturing them together. [J Tissue Eng Regen Med]

Alloreactivity Across HLA Barriers Is Mediated by Both Naïve and Antigen-Experienced T Cells
Findings conclusively show that alloresponses in man are not confined to the naïve T cell subset and that memory viral antigen-specific T cells can cross-react with specific mismatched human leukocyte antigen (HLA)-peptide complexes not presenting CMV or EBV peptides. [Biol Blood Marrow Transplant]

Use of Matched Unrelated Donors Compared with Matched Related Donors Is Associated with Lower Relapse and Superior Progression Free Survival After Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation
Results suggest that the use of unrelated donors is associated with greater graft-versus-leukemia activity than matched related donors, and could have practice changing impact on future donor selection in reduced intensity conditioning hematopoietic stem cell transplantation. [Biol Blood Marrow Transplant]

The Outcomes of Family Haploidentical Hematopoietic Stem Cell Transplantation in Hematological Malignancies Are Not Associated with Patient Age
Haploidentical hematopoietic cell transplantation has been used to treat hematologic malignancies but it is unknown whether the procedure is more effective in adults or children. To address this question, researchers analyzed patients aged 1-65 years old receiving myeloablative conditioning regimens. [Biol Blood Marrow Transplant]

Polychromatic Flow Cytometry Analysis of CD34+ Hematopoietic Stem Cells in Cryopreserved Early Preterm Human Cord Blood Samples
Results evidence the hematopoietic peculiarity of human early preterm cord blood, potentially useful for highlighting early steps of human hematolymphopoiesis as well as for developing novel strategies of stem cell-based therapy. [Cytometry A]

Cord Blood-Derived Cytokine-Induced Killer Cells Biotherapy Combined with Second-Line Chemotherapy in the Treatment of Advanced Solid Malignancies
Researchers concluded cord blood-derived cytokine-induced killer (CB-CIK) cells combined with second-line chemotherapy can significantly improve progression-free survival and median survival compared with second-line chemotherapy alone in patients with advanced solid malignancies after first-line chemotherapy failure. [Int Immunopharmacol]

Replicative Senescence of Human Bone Marrow and Umbilical Cord Derived Mesenchymal Stem Cells and Their Differentiation to Adipocytes and Osteoblasts
The study demonstrated p21 was important in the senescence of human bone-marrow (BM)-mesenchymal stem cells (MSC) and umbilical cord (UC)-MSC. C/EBPalpha and PPARgamma could regulate the balance of adipogenic differentiation in BM-MSC but only PPARgamma not C/EBPalpha was involved in the adipogenic differentiation in UC-MSC. [Mol Biol Rep]

Effect of Human Umbilical Cord Blood Progenitor Cells Versus Mononuclear Cells on Acute Renal Failure Rat Model
Researchers aimed to assess the ability of human umbilical cord blood CD34 cells and mononuclear cells to improve renal function of nephrotoxic kidney. [Curr Stem Cell Res Ther]

UTHealth Studies Cord Blood Stem Cells for Pediatric Traumatic Brain Injury
The University of Texas Health Science Center at Houston (UTHealth) has begun enrollment for the first Phase I safety study approved by the Food and Drug Administration to investigate the use of a child’s own umbilical cord blood stem cells for traumatic brain injury in children. [University of Texas Health Science Center at Houston Press Release]
 
Athersys Announces Completion of Patient Enrollment for Single Dose Arm of Phase I Study of MultiStem® for Hematopoietic Stem Cell Transplant Support
Athersys, Inc. announced that it has completed patient enrollment of the single dose arm of a clinical study involving administration of MultiStem® to patients being treated for leukemia or other blood born cancers. [Athersys, Inc. Press Release]

Legislation Seeks to Offer Affordable Storage of Stem Cells
Legislation has been introduced in New Jersey that would add a $5 fee to the cost of a birth certificate for the donation, processing and storage of umbilical cords. [New Jersey Office of Legislative Services, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)
 
Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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