Efficient Generation of Transgene-Free Induced Pluripotent Stem Cells from Normal and Neoplastic Bone Marrow and Cord Blood Mononuclear Cells Scientists demonstrated that induced pluripotent stem cells free of transgene and vector sequences could be efficiently generated from human bone marrow and cord blood mononuclear cells using non-integrating episomal vectors. [Blood] Tregs Prevent GvHD and Promote Immune Reconstitution in HLA-Haploidentical Transplantation The present study evaluated the impact of early infusion of T regulatory cells, followed by conventional T cells, on GvHD prevention and immunological reconstitution, in 28 patients with high risk hematological malignancies who underwent HLA-haploidentical hematopoietic stem cell transplantation. [Blood] CD34+ Hematopoietic Precursors Are Present in Human Decidua and Differentiate into Natural Killer Cells Upon Interaction with Stromal Cells Researchers discovered CD34+ hematopoietic precursors in human decidua (dCD34+). They show that dCD34+ cells differ from cord blood- or peripheral blood-derived CD34+ precursors. [Proc Natl Acad Sci U S A] Clinical-Scale Cultures of Cord Blood CD34+ Cells to Amplify Committed Progenitors and Maintain Stem Cell Activity Researchers developed a clinical-scale cord blood cell ex vivo procedure to enable an extensive expansion of committed progenitors, colony forming cells, without impairing very primitive hematopoietic stem cells. [Cell Transplant] Serious Infection Risk and Immune Recovery After Double Unit Cord Blood Transplantation Without Anti-Thymocyte Globulin Results suggest that double unit cord blood transplantation (CBT) without anti-thymocyte globulin (ATG) is associated with prompt T-cell recovery, and unlike CBT incorporating ATG, infection is rarely a primary cause of death. [Biol Blood Marrow Transplant] Long-Term Outcome of Human Herpesvirus-6 Encephalitis After Allogeneic Stem Cell Transplantation Researchers surveyed 197 patients who underwent allogeneic hematopoietic stem cell transplantation between January 2004 and March 2008 at our institution, and 8 (4.0%) were diagnosed as having human herpesvirus-6 encephalitis. [Biol Blood Marrow Transplant] A Human Thymic Epithelial Cell Culture System for the Promotion of Lymphopoiesis from Hematopoietic Stem Cells Researchers report for the first time a human thymic epithelial cell line that supports lymphopoiesis from cord blood and bone marrow hematopoietic progenitor cell. [Exp Hematol] Treosulfan-Based Preparative Regimens for Allo-HSCT in Childhood Hematological Malignancies: A Retrospective Study on Behalf of the EBMT Pediatric Diseases Working Party Children with high-risk and advanced hematological malignancies and high-risk of life-threatening regimen-related toxicity can be transplanted effectively and safely using treosulfan-based regimens. Particularly favorable results were achieved in myeloid malignancies and in children undergoing second hematopoietic stem cell transplantation (HSCT). [Bone Marrow Transplant] |