Cord Blood News Volume 3.08 | Mar 3 2011

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Chromatin Modifying Agents Promote the Ex Vivo Production of Functional Human Erythroid Progenitor Cells
Researchers have developed an ex vivo generated transfusion products composed of erythroid progenitor cells and precursors cells. [Blood]

Predicting Clonal Self-Renewal and Extinction of Hematopoietic Stem Cells
Results indicate that each hematopoietic stem cell (HSC) is programmed to have a finite life span. This program and the memory of the life span of the mother HSC are inherited by all daughter HSCs. In contrast, there was extensive heterogeneity in life spans between individual HSC clones. [Proc Natl Acad Sci U S A]

Alveolar Epithelial Cell Therapy with Human Cord Blood-Derived Hematopoietic Progenitor Cells
Researchers investigated the capacity of human umbilical cord blood-derived CD34+ hematopoietic progenitor cells to regenerate injured alveolar epithelium in newborn mice. [Am J Pathol]

Human T Cell Development in the Liver of Humanized NOD/SCID/IL-2R(Gamma)^null (NSG) Mice Generated by Intrahepatic Injection of CD34+ Human (h) Cord Blood(CB) Cells
Results demonstrate that the intrahepatic injection of hCD34+ CB cells can facilitate human T cell development in the livers of humanized NSG mice. [Clin Immunol]

Synergistic Effects of Growth Factors and Mesenchymal Stromal Cells for Expansion of Hematopoietic Stem and Progenitor Cells
The supportive effect of mesenchymal stromal cells on hematopoiesis can be significantly increased by addition of specific recombinant growth factors – especially in combination with stem cell factor, thrombopoietin and fibroblast growth factor 1. [Exp Hematol]

Severe Pruritus and Hypothermia as the Primary Manifestations of Human Herpes Virus-6 Encephalitis After Pediatric Cord Blood Transplantation
Viral encephalitis has a reported incidence of 1.2-4% in prospective evaluations of allogeneic hematopoietic stem cell transplantation patients. [Bone Marrow Transplant]

Open Cardiac Surgery in the First Hours of Life Using Autologous Umbilical Cord Blood
This article describes the first clinical experience of complete repair of complex critical congenital heart diseases in the first hours of life using autologous umbilical cord blood. [Eur J Cardiothorac Surg]

Protective Effects of Human Umbilical Cord Blood Stem Cell Intravitreal Transplantation Against Optic Nerve Injury in Rats
Via intravitreal transplantation, human umbilical cord blood stem cells resulted in a significant increase in the survival of the retinal ganglion cells, and improved pathological changes in the rat retina, following traumatic optic neuropathy. [Graefes Arch Clin Exp Ophthalmol]

Genecell International Underscores Importance of Cord Blood Stem Cells in Meeting Minority Marrow Needs
GeneCell International, an international leader in the processing and preservation of umbilical cord blood stem cells, announced that it seeks to address the shortage of cord blood available for minority patients. [PRWeb]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 2nd International Hematologic Malignancies Conference: Bridging the Gap 2011
March 18-20, 2011
Singapore, Singapore

NEW The International Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM)
September 8-11, 2011
Berlin, Germany

NEW American Association of Blood Banks Annual Meeting & CTTXPO 2011
October 22-25, 2011
San Diego, United States

NEW World Cord Blood Congress III: Cord Blood Transplantation and Immunobiology of Haematopoietic Stem Cell Transplant
October 27-30, 2011
Rome, Italy

NEW Cell Therapy Manufacturing – Stem Cells and Immunotherapeutics
December 1-2, 2011
London, United Kingdom

NEW Stem Cell Programming & Reprogramming
December 8-11, 2011
Lisbon, Portugal

Visit our events page to see a complete list of events in the cord blood community.

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Cell Therapy Manufacturing Manager (Opexa Therapeutics)

Postdoctoral Fellow (The Henry M. Jackson Foundation)

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