Hepatic Differentiation of Amniotic Epithelial Cells Amniotic epithelial cells possess the ability to differentiate into cells with characteristics of functional hepatocytes, in vitro and in vivo, thus representing a useful and non controversial source of cells for transplantation. [Hepatology] Allogeneic Hematopoietic Stem Cell Transplantation Overcomes the Adverse Prognostic Impact of CD20 Expression in Acute Lymphoblastic Leukemia Results can serve as a reference to evaluate incorporation of anti-CD20 therapeutics to hematopoietic stem cell transplantation for the CD20+ acute lymphoblastic leukemia subset. [Blood] Autologous Stem Cell Transplantation as a First-Line Treatment Strategy for Chronic Lymphocytic Leukemia: A Multicenter Randomized Controlled Trial Researchers conducted a prospective randomized trial of autologous stem cell transplantation in previously untreated chronic lymphocytic leukemia patients. [Blood] Cardiac Tamponade Potentially Related to Sirolimus Following Cord Blood Transplantation Researchers present the case of a 28-year-old female patient with advanced myelodysplastic syndrome. [Bone Marrow Transplant] Initial CD34+ Cell-Enrichment of Cord Blood Determines Hematopoietic Stem/Progenitor Cell Yield Upon Ex Vivo Expansion Findings stress the importance of establishing a balance between the cell proliferative potential and cell recovery upon purification, towards the efficient and cost-effective expansion of hematopoietic stem/progenitor cells for cellular therapy. [J Cell Biochem] Ex Vivo Rapamycin Treatment of Human Cord Blood CD34+ Cells Enhances Their Engraftment of NSG Mice Since overexpression of Rheb2 leads to increased signaling through mTOR, researchers examined the effect of the mTOR inhibitor rapamycin ex vivo on cytokine expanded CD34+ cord blood cells for the engraftment of these cells in non-obese diabetic, severe combined immunodeficient, IL-2 receptor γ chain null (NSG) mice. [Blood Cells Mol Dis] Secondary Pulmonary Alveolar Proteinosis After Unrelated Cord Blood Hematopoietic Cell Transplantation Researchers observed two cases of pulmonary alveolar proteinosis after unrelated cord blood hematopoietic progenitor cell transplantation in children with ALL. [Pediatr Transplant] The Methods Used to Collect Hematopoietic Stem Cells The methods used to collect hematopoietic stem cells in their natural environment (bone marrow or cord blood) or in the peripheral blood after stimulation are well-defined and ruled both to ensure the donor security and perform a quality hematopoietic transplantation. [Transfus Clin Biol] |