Cord Blood News Volume 3.13 | Apr 7 2011

Impact of Immune Modulation with Anti-T Cell Antibodies on Outcomes of Reduced Intensity Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies
Data suggest adopting a cautious approach to routine use of in vivo T-cell depletion with alkylating reduced intensity conditioning regimens. [Blood]

Human Mast Cell Degranulation and Preformed TNF Secretion Require Mitochondrial Translocation to Exocytosis Sites: Relevance to Atopic Dermatitis
Stimulation of human umbilical cord blood-derived mast cells with IgE/antigen or Laboratory of Allergic Diseases 2 cells with substance P leads to rapid (30 minutes) secretion of preformed TNF. [J Allergy Clin Immunol]

What Are a Patient’s Current Chances of Finding a Matched Unrelated Donor? Twenty Years’ Central Search Experience in a Small Country
The strongest factor for both finding a donor and being transplanted was a search being performed during more recent years: patients’ chances increased from year to year. [Bone Marrow Transplant]

Improved Engraftment with Minimal Graft-Versus-Host Disease After Major Histocompatibility Complex-Mismatched Cord Blood Transplantation with Photochemically Treated Donor Lymphocytes
Researchers observed inconsistent donor engraftment after transplantation with cord blood alone, but superior engraftment and long-term survival after fetal near-term peripheral blood transplantation supplemented with psoralen-treated donor T-lymphocytes. [Exp Biol Med]

Optimization of In Vitro Erythropoiesis from CD34+ Cord Blood Cells Using Design of Experiments (DOE)
Researchers used design of experiments methodology to quantitatively define and optimize in vitro erythropoiesis from human cord blood CD34+ cells to enucleation. [Biochem Eng J]

Outcomes, Infections, and Immune Reconstitution After Double Cord Blood Transplantation in Patients with High-Risk Hematological Diseases
Delayed immune recovery and high incidence of infectious complications were observed after double unrelated cord blood transplant in patients with high-risk hematological diseases. [Transpl Infect Dis]

Umbilical Cord Blood Cell Transplantation After Brain Ischemia – From Recovery of Function to Cellular Mechanisms
The therapeutic functional effects of human umbilical cord blood (hUCB) cells observed in animal models make the transplantation of hUCB cells a promising experimental approach in the treatment of ischemic brain injury. [Ann Anat]

Allogeneic Hematopoietic Stem Cell Transplantations
The present experience shows clearly that the allogeneic hematopoietic stem cell transplantation strategy should be developed and refined because of the potential benefit that can be expected in some patients’ sub-groups and then allogeneic hematopoietic stem cell transplantation, real immunotherapy should be included in the global therapeutic strategy in onco-hematology. [Transfus Clin Biol]

Report to Nation Finds Continued Declines in Many Cancer Rates
Rates of death in the United States from all cancers for men and women continued to decline between 2003 and 2007, the most recent reporting period available, according to the latest Annual Report to the Nation on the Status of Cancer. [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Discussion Workshop: Stem Cells
May 6, 2011
London, United Kingdom

NEW 2011 American Society of Clinical Oncology Annual Meeting
June 3-7, 2011
Chicago, United States

NEW 2011 World Stem Cell Summit
October 3-5, 2011
Pasadena, United States

NEW Society for Maternal-Fetal Medicine 32nd Annual Meeting
February 6-11, 2012
Dallas, United States

NEW The 2012 London Regenerative Medicine Event
February 16, 2012
London, United Kingdom

Visit our events page to see a complete list of events in the cord blood community.

Implementation Coordinator – Maternity Leave Contract (STEMSOFT Software Inc.)

Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Supervisor Cell Therapy Laboratory – Cord Blood Bank (The University of Texas MD Anderson Cancer Center)

Supervisor Cell Therapy Lab (The University of Texas MD Anderson Cancer Center)

Cell Therapy Manufacturing Manager (Opexa Therapeutics)

Research Associate (University College London Institute of Child Health)

INTERBIO-21st Project Coordinator (University of Oxford – Nuffield Department of Obstetrics & Gynaecology)

Senior Scientist (Matchtech)

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