STAT3-Dependent IL-21 Production from T Helper Cells Regulates Hematopoietic Progenitor Cell Homeostasis Researchers demonstrated that hematopoietic progenitor cell activity is decreased in mice with STAT3-deficient T cells, a phenotype that is not due to decreased expression of IL-17 or RORγt. [Blood] Alemtuzumab with Fludarabine and Cyclophosphamide Reduces Chronic Graft Versus Host Disease After Allogeneic Stem Cell Transplantation for Acquired Aplastic Anemia Researchers evaluated a novel alemtuzumab-based conditioning regimen in hematopoietic stem cell transplantation for acquired severe aplastic anemia. [Blood] Novel Measurements of Mammary Stem Cells in Human Umbilical Cord Blood as Prospective Predictors of Breast Cancer Susceptibility in Later Life The positive association between measurable breast and hematopoietic stem cells in human umbilical cord blood suggests plausible mechanisms for a prenatal influence on breast cancer risk. [Ann Oncol] Red Blood Cells from Induced Pluripotent Stem Cells: Hurdles and Developments The most proliferative source of stem cells for generating cultured red blood cells is the cord blood, but this source is limited in terms of hematopoietic stem cells and dependent on donations. [Curr Opin Hematol] CD11b and CD27 Reflect Distinct Population and Functional Specialization in Human Natural Killer Cells Nearly all natural killer (NK) cells from peripheral blood are CD11b+ CD27− populations whereas NK cells from cord blood have CD11b+ CD27− and CD11b+ CD27+ populations. [Immunology] Factors Influencing the Outcome of a Second Autologous Stem Cell Transplant (ASCT) in Relapsed Multiple Myeloma: A Study from the British Society of Blood and Marrow Transplantation Registry Second ASCT in relapsed multiple myeloma is associated with superior OS and PFS compared to conventional chemotherapy, offering a potential consolidative option for selected patients. [Biol Blood Marrow Transplant] Humanized Substitutes for Animal Sera in Human Mesenchymal Stem Cell Culture and Differentiation This study investigates the use of two ‘human-derived’ supplements, namely human platelet lysate and umbilical cord blood serum, in human mesenchymal stem cell culture. [Cell Biol Int] Successful Neutrophil Engraftment by Reduced Use of Granulocyte Colony-Stimulating Factor After Allogeneic Hematopoietic Stem Cell Transplantation with Mycophenolate Mofetil for Graft-Versus-Host Disease Prophylaxis Researchers compared the clinical outcomes between a standard dose (SD) fixed at 300 μg per day and a high dose (HD) of granulocyte colony-stimulating factor (G-CSF). While time to neutrophil engraftment was not different in the HD and SD groups in patients receiving cord blood transplantation (CBT, 20 vs. 17.5 days, P = 0.243) or bone marrow transplantation (BMT, 11 vs. 10 days, P = 0.227), there seemed to be an increased risk of developing acute GVHD in the HD group with CBT (20 vs. 0%, P = 0.073) and BMT (57 vs. 24%, P = 0.165). [Int J Hematol] |