| SCIENCE NEWS | Queen’s Scientists Teaming Up to Cure Premature Baby Blindness Two teams are taking different approaches to a condition called Retinopathy of Prematurity (ROP). The first team has the aim of tackling the disease at a very early stage, which will minimise the damaging effects of ROP. The second team is investigating whether stem cells from babies’ own umbilical cords might have the power to repair their damaged eyes and save their sight. [Queen’s University Belfast Press Release] |
| CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) | Methodological Development of a Clonogenic Assay to Determine Endothelial Progenitor Cell Potential This assay further enables a proper exploration of possible links between the origin of endothelial progenitor cells (EPC) and hematopoietic stem cells, representing a novel and powerful tool to investigate the molecular signaling pathways involved in EPC biology. [Circ Res] A 3D Aligned Microfibrous Myocardial Tissue Construct Cultured Under Transient Perfusion The basic 3D construct design involved two biodegradable macroporous tubes, to allow transport of growth media to the cells within the construct, and cell seeded, aligned fiber mats wrapped around them. The microfibrous mat housed mesenchymal stem cells from human umbilical cord matrix (Wharton’s Jelly) aligned in parallel to each other in a similar way to cell organization in native myocardium. [Biomaterials] Human Umbilical Mesenchymal Stem Cells Promote Recovery After Ischemic Stroke Here researchers evaluate the therapeutic potential of human umbilical mesenchymal stem cell transplantation for ischemic stroke in rats. [Stroke] Outcome of Unrelated Umbilical Cord Blood Transplantation in 88 Patients with Primary Immunodeficiency in Japan Researchers report the results of umbilical cord blood transplantation performed in 88 patients with primary immunodeficiency between 1998 and 2008 in Japan; severe combined immunodeficiency (SCID, n = 40), Wiskott–Aldrich syndrome (WAS, n = 23), chronic granulomatous disease (n = 7), severe congenital neutropaenia (SCN, n = 5) and other immunodeficiencies (n = 13). [Br J Haematol] Human Umbilical Cord Blood-Derived Mononuclear Cell Transplantation: Case Series of 30 Subjects with Hereditary Ataxia This open label treatment study used human umbilical cord blood-derived mononuclear cells combined with rehabilitation training as potential disease modulators. [J Transl Med] Umbilical Cord Blood as a Replacement Source for Admission Complete Blood Count in Premature Infants Researchers hypothesized that a complete blood count (CBC) with manual differential from umbilical cord blood is equivalent to a CBC with manual differential obtained from the neonate on admission. [J Perinatol] Ionized Calcium Levels in Umbilical Cord Blood of Women with Preeclampsia and Normotensive Pregnancies The objective of the study was to investigate ionized calcium levels in the umbilical cord arterial blood of women with preeclampsia and normotensive pregnancies. [J Matern Fetal Neonatal Med] Trace Elements’ Concentrations in Maternal and Umbilical Cord Plasma at Term Gestation: A Comparison between Active Labor and Elective Cesarean Delivery This study was aimed to determine levels of trace elements’ concentration in maternal plasma and umbilical venous and arterial plasma at term during active labor vs elective cesarean delivery. [J Matern Fetal Neonatal Med] Umbilical sP-Selectin Levels are Different in Preeclamptic Pregnancies with Intrauterine Normal Growth and Growth Restricted Fetus The aim of this study was the analysis of the umbilical cord serum sP-selectin levels in pregnancies complicated by severe preeclampsia with and without intrauterine growth restriction and in normotensive pregnancies. [J Matern Fetal Neonatal Med] Improving the Efficacy of Type 1 Diabetes Therapy by Transplantation of Immunoisolated Insulin-Producing Cells The results provide further evidence supporting the use of allogeneic or xenogeneic mesenchymal stem cells obtained from bone marrow or umbilical cord blood for treating type 1 diabetes. [Hum Cell] |
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