Cord Blood News Volume 3.32 | Aug 18 2011

Stable Long-Term Pulmonary Function After Myeloablative Double Cord Blood Transplant
Researchers performed a retrospective analysis of patients who underwent double cord blood transplantation following myeloablative conditioning. [Biol Blood Marrow Transplant]

‘D’ Deficit Boosts Food Sensitivity Risk
A study examined whether cord blood vitamin D deficiency was associated with food sensitization and whether the association could be modified by genetic variants. [Press release from ModernMedicine discussing online prepublication in Allergy]

Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia
Researchers report that in chronic lymphocytic leukemia, the propensity to generate clonal B cells has been acquired already at the hematopoietic stem cell stage. [Cancer Cell]

Sox17 Expression Confers Self-Renewal Potential and Fetal Stem Cell Characteristics Upon Adult Hematopoietic Progenitors
In the current study, scientists show that ectopic expression of Sox17 in adult hematopoietic stem cells (HSCs) and transiently reconstituting multipotent progenitors was sufficient to confer increased self-renewal potential and the expression of fetal HSC genes, including fetal HSC surface markers. [Genes Dev]

IFN-γ Promotes Graft-Versus-Leukemia Effects without Directly Interacting with Leukemia Cells in Mice After Allogeneic Hematopoietic Cell Transplantation
The ability of IFN-γ to enhance graft-versus-leukemia (GVL) activity without direct interaction with leukemia cells was examined by comparing GVL effects against IFN-γ receptor-deficient leukemia between wild-type and IFN-γ-deficient allogeneic hematopoietic cell transplantation. [Blood]

C-Terminal Mutation of RUNX1 Attenuates the DNA-Damage Repair Response in Hematopoietic Stem Cells
Here, scientists report that the C-terminal deletion mutant of RUNX1, RUNX1dC, attenuates DNA-damage repair responses in hematopoietic stem/progenitor cells. [Leukemia]

CpG Methylation Patterns and Decitabine Treatment Response in Acute Myeloid Leukemia Cells and Normal Hematopoietic Precursors
High expression of lineage-specifying factor and aberrant epigenetic repression of some key late-differentiation driver genes distinguishes acute myeloid leukemia cells from normal hematopoietic stem cells, and could explain the contrasting differentiation and methylation responses to decitabine. [Leukemia]

Gene–Vitamin D Interactions on Food Sensitization: A Prospective Birth cohort Study
Researchers aimed to examine whether cord blood vitamin D deficiency is associated with food sensitization and whether such association can be modified by genetic variants in a prospective birth cohort. [Allergy]

FcγRIIIa (CD16) Induction on Human T Lymphocytes and CD16^pos T-Lymphocyte Amplification
To identify the T-cell compartment from which αβ T-cell receptor CD16^pos T cells originated (naive, antigen experienced, CD16^pos, or CD16^neg), researchers first compared the results obtained with HIV+ patients’ peripheral blood mononuclear cells (PBMCs) with those obtained from cord blood lymphocytes and PBMC from healthy donors. [J Immunother]

Intratracheal Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Attenuates Escherichia coli-Induced Acute Lung Injury in Mice
Researchers hypothesized that intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells could attenuate Escherichia coli-induced acute lung injury in mice by suppressing the inflammatory response. [Respir Res]

Negative Regulation of Cyclin D3 Expression by Transcription Factor c-Ets1 in Umbilical Cord Hematopoietic Cells
The aim was to investigate the role of transcription factor c-Ets1 in cyclin D3 expression and its effects on the proliferation of umbilical cord hematopoietic cells. [Acta Pharmacol Sin]

Successful Cord Blood Transplantation with Reduced-Intensity Conditioning for Childhood Cerebral X-Linked Adrenoleukodystrophy at Advanced and Early Stages
The reduced-intensity conditioning researchers used was sufficient for stable engraftment of cord blood and also tolerable even to the patient with advanced adrenoleukodystrophy. [Pediatr Transplant]

Cord Blood America Revenues Up 61 Percent
Cord Blood America, Inc. announced revenues of $2.89 million for the first six months of 2011, up 61 percent compared to revenues of $1.79 million in the same period in 2010. [Cord Blood America, Inc. Press Release]

Cord Blood America Opens Office in Middle East
Cord Blood America, Inc. announced that Stellacure, GmbH, its stem cell company headquartered in Hamburg, Germany, has entered into an agreement with a licensee in Jordan to open an umbilical cord blood stem cell company in that Middle East nation. [Cord Blood America, Inc. Press Release]

Umbilical Cord Blood Bill Passed into Law
New York Assemblyman Joseph R. Lentol announced the signing of the Umbilical Cord Blood Bill into law by Governor Eliot Spitzer, Chapter 427 of 2007. [PR Newswire]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW International Society for Cell Therapy North American Regional Meeting
September 14-16, 2011
Charlottesville, United States 

Visit our events page to see a complete list of events in the cord blood community.

Lab Technologist – Tissue Culture (STEMCELL Technologies) 

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies) 

Research and Development Technologist (STEMCELL Technologies) 

Cord Blood Procurement Specialist (Karmanos Cancer Institute)

Postdoctoral Positions in Stem Cells and Immunology (University of Connecticut) 

Recruit Top Talent
Reach more than 11,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Jobs are categorized regionally: United States, Canada, Europe, Asia Pacific

Visit here to post your career opportunities.

Have we missed an important article or publication in Cord Blood News? Click here to submit!

Comments or Suggestions? Email info@connexoncreative.com with your feedback.