Immunological Applications of Stem Cells in Type 1 Diabetes Cord blood stem cells have been shown to facilitate the generation of regulatory T cells, thereby reverting hyperglycemia in nonobese diabetic mice. [Endocr Rev] Hematopoietic Cells as Sources for Patient-Specific iPSCs and Disease Modeling Here researchers describe the recent advances in generating disease specific human induced pluripotent stem cells (iPSCs) from the different types of hematopoietic cells and their potential applications in disease modeling and regenerative medicine. [Cell Cycle] Mesenchymal Stem Cells Inhibit Thymic Reconstitution After Allogeneic Cord Blood Transplantation The results highlight the importance of close monitoring of the immune reconstitution after cord blood transplantation. In addition it shows a potentially new suppressive effect of mesenchymal stem cells on the immune system. [Stem Cells Dev] Collagen-Calcium Phosphate Cement Scaffolds Seeded with Umbilical Cord Stem Cells for Bone Tissue Engineering The objectives of this study were to develop a novel class of collagen-calcium phosphate cement (CPC) composite scaffolds, and to investigate human umbilical cord mesenchymal stem cell attachment, proliferation, and osteogenic differentiation on collagen-CPC scaffolds for the first time. [Tissue Eng Part A] Successful In Vitro Expansion and Differentiation of Cord Blood Derived CD34+ Cells into Early Endothelial Progenitor Cells Reveals Highly Differential Gene Expression Herein, investigators describe an in vitro culture technique with the aim to generate high numbers of phenotypically, functionally and genetically defined early endothelial progenitor cells from human cord blood. [PLoS One] Intra-Bone Marrow Transplantation of Unwashed Cord Blood Using Reduced-Intensity Conditioning Treatment: A Phase I Study Researchers found that intra-bone marrow injection of unwashed cord blood following reduced-intensity conditioning is safe, well tolerated, and may lead to an increased donor engraftment rate. [Biol Blood Marrow Transplant] Long-Term Follow-Up of Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia: Impact of Tyrosine Kinase Inhibitors on Treatment Outcomes A retrospective analysis was conducted on 102 adults and 11 children who received a first matched related (n=60), matched unrelated (n=40), mismatched cord blood (n=12), or haplo-identical (n=1) allogeneic hematopoietic stem cell transplant for Philadelphia chromosome positive acute lymphoblastic leukemia in first complete remission (n=71), second complete remission (n=11) or with active disease (n=31) between 1990 and 2009. [Biol Blood Marrow Transplant] A Novel Method for Human Hematopoietic Stem/Progenitor Cell Isolation from Umbilical Cord Blood Based on Immunoaffinity Aqueous Two-Phase Partitioning A novel cell separation process based on immunoaffinity aqueous two phase systems is presented to isolate and purify CD34+ stem/progenitor cells directly from the whole umbilical cord blood. [Biotechnol Lett] Transplantation of Human Umbilical Cord Blood Mesenchymal Stem Cells Improves Survival Rates in a Rat Model of Acute Hepatic Necrosis This study aimed to evaluate the effects of human umbilical cord blood mesenchymal stem cell transplantation in acute hepatic necrosis. [Am J Med Sci] |