Polymorphisms in Genes That Regulate Cyclosporine Metabolism Affect Cyclosporine Blood Levels and Clinical Outcomes in Patients Who Receive Allogeneic Hematopoietic Stem Cell Transplantation In patients who received allogeneic hematopoietic stem cell transplantation, researchers investigated the correlations between single nucleotide polymorphisms in genes that regulate cyclosporine metabolism and clinical outcomes. [Blood] Abstract Significant Clinical, Neuropathological and Behavioural Recovery from Acute Spinal Cord Trauma by Transplantation of a Well-Defined Somatic Stem Cell from Human Umbilical Cord Blood Here, researchers have transplanted a well-defined unrestricted somatic stem cell isolated from human umbilical cord blood into an acute traumatic spinal cord injury of adult immune suppressed rat. [Brain] Abstract Neurogenic Properties and a Clinical Relevance of Multipotent Stem Cells Derived from Cord Blood Samples Stored in the Biobanks Scientists showed in this study that multipotent stem cells derived from fresh and frozen cord blood samples could be efficiently induced in defined serum-free medium toward neuronal progenitors (NF200+, Ki67+). [Stem Cells Dev] Abstract Therapeutic Efficacy of Cord Blood-Derived Mesenchymal Stromal Cells for the Prevention of Acute GVHD in a Xenogenic Mouse Model Here, researchers tested the ability of cord blood-derived mesenchymal stromal cells to alleviate the symptoms of graft-versus-host disease induced by the injection of human peripheral blood mononuclear cells into NOD/SCID/γc- mice. [Stem Cells Dev] Abstract Combination of Low O2 Concentration and Mesenchymal Stromal Cells During Culture of Cord Blood CD34+ Cells Improves the Maintenance and Proliferative Capacity of Hematopoietic Stem Cells The data demonstrate that association of co-culture and low O2 concentration not only induces sufficient expansion of committed progenitors (with respect to the classical culture), but also ensures a better maintenance/expansion of hematopoietic stem cells, pointing to the oxygenation as a physiological regulatory factor but also as a cell engineering tool. [J Cell Physiol] Abstract Recurrence of Monoclonal Gammopathy Associated with Donor-Derived Myelodysplastic Syndrome After Cord Blood Stem Cell Transplantation Investigators report a patient who developed donor-derived myelodysplastic syndrome (MDS) followed by leukemic transformation after cord blood transplantation for MDS with monoclonal gammopathy. [Exp Hematol] Abstract Profiling of Immune-Related MicroRNA Expression in Human Cord Blood and Adult Peripheral Blood Cells Upon Proinflammatory Stimulation The aim was to elucidate the molecular mechanism underlying the immune response of cord blood (CB)-derived cells during acute graft-versus-host disease and infection following CB transplantation. [Eur J Haematol] Abstract In Vitro Effects of Stromal Cells Expressing Different Levels of Jagged-1 and Delta-1 on the Growth of Primitive and Intermediate CD34+ Cell Subsets from Human Cord Blood Researchers assessed the effects of the OP9 stroma cell line – naturally expressing Jagged-1 – transduced with either the Delta-1 gene (OP9-DL1 cells) or with vector alone (OP9-V), on the in vitro growth of two different hematopoietic cell populations. [Blood Cells Mol Dis] Abstract Ex Vivo Differentiation of Natural Killer Cells from Human Umbilical Cord Blood CD34+ Progenitor Cells Researchers have explored the capacities of natural killer-cells after differentiation from hematopoietic stem and progenitor cells derived from human umbilical cord blood. [Cell Commun Adhes] Abstract |