Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells Here scientists show that the requirements for core binding factor β in erythroid/myeloid progenitor and hematopoietic stem cell formation in the conceptus are temporally and spatially distinct. [Cell Stem Cell] Abstract Expansion of Functionally Defined Mouse Hematopoietic Stem/Progenitor Cells by a Short Isoform of RUNX1/AML1 Findings establish the short isoform of RUNX1/AML1 as an isoform-specific molecule that can influence several transcriptional regulators associated with hematopoietic stem cells, leading to enhanced self-renewal activity and hematopoietic stem/progenitor cell expansion ex vivo and in vivo. [Blood] Abstract Importance of Day 21 BM Chimerism in Sustained Neutrophil Engraftment following Double-Unit Cord Blood Transplantation Researchers analyzed the association between BM assessment performed approximately 21 days after transplantation, and the speed and success of sustained donor-derived neutrophil engraftment in 56 myeloablative double-unit cord blood transplantation recipients. [Bone Marrow Transplant] Abstract Differential Impact of Inhibitory and Activating Killer Ig-Like Receptors (KIR) on High-Risk Patients with Myeloid and Lymphoid Malignancies Undergoing Reduced Intensity Transplantation from Haploidentical Related Donors The impact of activating KIR and inhibitory KIR on OS, relapse-related mortality and acute GVHD was prospectively studied in 84 adults with high-risk hematologic malignancies receiving reduced intensity conditioning T-cell depleted hematopoietic SCT from haploidentical related donors. [Bone Marrow Transplant] Abstract Optimizing a Photoallodepletion Protocol for Adoptive Immunotherapy after Haploidentical SCT Investigators determined the efficacy of photodynamic purging of alloreactive T cells, by investigating combinations of parameters in order to achieve maximum allodepletion, preservation of T-regulatory cells and of pathogen and leukemia-specific T-cell responses in donor-vs-recipient MLR. [Bone Marrow Transplant] Abstract Initial Cord Blood Unit Volume Affects Mononuclear Cell and CD34+ Cell-Processing Efficiency in a Non-Linear Fashion The present study focused on parameters influencing total nucleated cell, mononucleated cell and CD34+ cell recovery after routine volume reduction of 1553 umbilical cord blood units using hydroxyethyl starch-induced sedimentation with an automated device, under routine laboratory conditions. [Cytotherapy] Abstract Functional Characterization of Transmembrane Intracellular pH Regulators and Mechanism of Alcohol-Induced Intracellular Acidosis in Human Umbilical Cord Blood Stem Cell–Like Cells The aims of the present study were to investigate the physiological mechanisms of intracellular pH (pHi) recovery and to further explore the effects of alcohol on the pHi in human umbilical cord blood CD34+ stem cell–like cells. [J Cardiovasc Pharmacol] Abstract Viability and Neural Differentiation of Mesenchymal Stem Cells Derived from the Umbilical Cord following Perinatal Asphyxia The aim of this study was to examine the capacity for mesenchymal stem cells to differentiate into neural tissue that could subsequently be used for autologous transplantation. [J Perinatol] Abstract |