Cord Blood News Volume 4.03 | Jan 26 2012

ETV6–PDGFRB and FIP1L1–PDGFRA Stimulate Human Hematopoietic Progenitor Proliferation and Differentiation into Eosinophils: Role of NF-κB
Researchers introduced ETV6–PDGFRB and FIP1L1–PDGFRA in human CD34+ hematopoietic progenitors and stem cells isolated from umbilical cord blood. [Haematologica] Abstract

Cord Blood Stem Cell-Derived DCs Generate Potent Antigen-Specific Immune Responses and Anti-Tumor Effects
This study aims to evaluate if cord blood stem cells can be new source of dendritic cells (DCs) which can generate more potent antigen-specific immune responses and anti-tumor effects. [Clin Sci] Abstract

Endothelial Progenitor Cells (EPCs) as Gene Carrier System for Rat Model of Human Glioma
The purposes of this study were to investigate whether intravenously administered, genetically transformed cord blood derived EPCs can carry human sodium iodide symporter to the sites of tumors in rat orthotopic model of human glioma and express transgene products, and whether accumulation of these administered EPCs can be tracked by different in vivo imaging modalities. [PLoS One] Abstract

Bioadhesive Control of Plasma Proteins and Blood Cells from Umbilical Cord Blood onto the Interface Grafted with Zwitterionic Polymer Brushes
In this work, bioadhesive behavior of plasma proteins and blood cells from umbilical cord blood onto a zwitterionic poly(sulfobetaine methacrylate) polymer brushes was studied. [Langmuir] Abstract

Isolation, Characterization and Differentiation of Mesenchymal Stem Cells from Amniotic Fluid, Cord Blood and Wharton’s Jelly in the Horse
This work aimed to identify and characterize stem cells from equine amniotic fluid, cord blood and Wharton’s jelly. [Reproduction] Abstract

Mesenchymal Stromal Cells Derived from Umbilical Cord Blood Migrate in Response to Complement C1q
Researchers found that complement component 1 subcomponent q (C1q) chemoattracted human umbilical cord blood-derived mesenchymal stromal cells (MSC) in a dose-dependent manner and that the receptor for the global domains of C1q is present on the surface of MSC. [Cytotherapy] Abstract

Hypoxia Improves Expansion Potential of Human Cord Blood-Derived Hematopoietic Stem Cells and Marrow Repopulation Efficiency
The objective of this investigation was to compare cellular, functional and molecular responses of human umbilical cord blood-derived hematopoietic stem and progenitor cells in culture under hypoxic and normoxic conditions. [Eur J Haematol] Abstract

Inhibition of p38 MAPK Activity Promotes Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem Cells
Investigators examined the effect of inhibition of p38 mitogen-activated protein kinase (p38) on the expansion of human umbilical cord blood CD133⁺ cells because activation of p38 has been implicated in the induction of hematopoietic stem cell senescence under various physiological and pathological conditions. [Ann Hematol] Abstract

Canada’s First National Public Cord Blood Bank Adopts Thermogenesis Bioarchive Cryopreservation System
ThermoGenesis Corp. said it had received an initial order for its BioArchive^® System from a new public cord blood bank that will begin operations in Canada in early 2013. [ThermoGenesis Corp.] Press Release

Celldex Therapeutics Announces Initiation of Phase I Clinical Trial of CDX-301
Celldex Therapeutics, Inc. announced that dosing has initiated in a Phase I study of its hematopoietic growth factor, CDX-301, in healthy subjects. [Celldex Therapeutics, Inc.] Press Release

Maryland Stem Cell Research Commission Announces New Program for Pre-Clinical and Clinical Research Grants
The Maryland Stem Cell Research Commission has announced a new program for pre-clinical and clinical research grants. This program will support for-profit companies in advancing medical therapies using human stem cells. [Maryland Stem Cell Research Fund] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the cord blood community.

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Laboratory Supervisor – Cellular Therapy (NewYork-Presbyterian Hospital)

Pediatric Faculty – Hematology/Oncology Stem Cell Sciences (The University of Chicago)


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