Cord Blood News Volume 4.05 | Feb 9 2012

Rapid Expansion of Human Hematopoietic Stem Cells by Automated Control of Inhibitory Feedback Signaling
Herein researchers describe an integrated computational and experimental strategy that enables a tunable reduction in the global levels and impact of paracrine signaling factors in an automated closed-system process by employing a controlled fed-batch media dilution approach. Application of this system to human cord blood cells yielded a rapid (12-day) 11-fold increase of hematopoietic stem cells with self-renewing, multilineage repopulating ability. [Cell Stem Cell] Abstract

Novel Pathways to Erythropoiesis Induced by Dimerization of Intracellular cMpl in Human Hematopoietic Progenitors
The goal of this study was to define the hematopoietic progenitor stages at which dimerization of intracellular Mpl induces erythropoiesis, and the downstream molecular events that mediate this unanticipated effect. [Stem Cells] Abstract

Combinatorial Human Progenitor Cell Transplantation Optimizes Islet Regeneration through Secretion of Paracrine Factors
To identify paracrine effectors produced by islet-regenerative multipotent-stromal cells (MSC), culture-expanded bone marrow (BM) high ALDH-activity (ALDHhi) MSC were transplanted into STZ-treated NOD/SCID mice and segregated into islet-regenerative versus non-regenerative cohorts based on hyperglycemia reduction, and subsequently compared for differential production of mRNA and secreted proteins. Co-culture with umbilical cord blood ALDHhi cells induced beta cell but not ductal epithelial cell proliferation. [Stem Cells Dev] Abstract

Ex Vivo Fucosylation Improves Human Cord Blood Engraftment in NOD-SCID IL-2Rγnull (NSG) Mice
By isolating fucosylated and non-fucosylated CD34⁺ cells from cord blood researchers show that only fucosylated CD34⁺ cells are responsible for engraftment in NSG mice. [Exp Hematol] Abstract

Basic Fibroblast Growth Factor Modulates Cell Cycle of Human Umbilical Cord-Derived Mesenchymal Stem Cells
This study has aimed to establish optimum conditions to generate and characterize mesenchymal stem cells from the human umbilical cord. [Cell Prolif] Abstract

Extracellular Nucleotide Inhibits Cell Proliferation and Negatively Regulates Toll-Like Receptor 4 Signaling in Human Progenitor Endothelial Cells
In the present study, researchers analyzed the expression and the function of P2 receptors in human umbilical cord blood-derived EPCs. [Cell Biol Int] Abstract

Allogeneic Transplantation of Umbilical Cord-Derived Mesenchymal Stem Cells for Diffuse Alveolar Hemorrhage in Systemic Lupus Erythematosus
This study aimed to assess the efficacy of umbilical cord-derived mesenchymal stem cell transplantation in the treatment of systemic lupus erythematosus-associated diffuse alveolar hemorrhage. [Clin Rheumatol] Abstract

Cytomedix Expands Commitment to Regenerative Medicine with Acquisition of Aldagen
Cytomedix, Inc. announces the completion of the acquisition of Aldagen, Inc., a privately held biopharmaceutical company developing regenerative cell therapies based on its proprietary ALDH bright cell technology. [Cytomedix, Inc.] Press Release

$30 Million Gift to Fast Forward Health Care Research, Education and Care at McMaster University
A Hamilton family is giving McMaster University $30 million to accelerate the university’s innovations in health research, education and care. Of the total, $24 million is designated to establish The Boris Family Centre in Human Stem Cell Therapies. [McMaster University] Press Release

Pluristem to Expand Research & Development of Radiation Exposure Treatment
Pluristem Therapeutics, Inc. announced that following preliminary discussions with several governmental authorities, it will expand its research and development efforts on an acute radiation exposure treatment. [Pluristem Therapeutics, Inc.] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 52nd British Society for Haematology (BSH) Annual Scientific Meeting
April 16-18, 2012
Glasgow, United Kingdom

NEW World Stem Cells & Regenerative Medicine Congress 2012
May 21-23, 2012
London, United Kingdom

Visit our events page to see a complete list of events in the cord blood community.

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Laboratory Supervisor – Cellular Therapy (NewYork-Presbyterian Hospital)

Pediatric Faculty – Hematology/Oncology Stem Cell Sciences (The University of Chicago)

Cord Blood Technologist (New York Blood Center)

Postdoctoral Position – Stem Cell Research (Tsinghua University Graduate School at Shenzhen)


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