Cord Blood News Volume 4.11 | Mar 22 2012

Therapeutic Benefit of Treatment of Stroke with Simvastatin and Human Umbilical Cord Blood Cells: Neurogenesis, Synaptic Plasticity and Axon Growth
Researchers hypothesized that Simvastatin increases human umbilical cord blood cell migration into the ischemic brain and promotes brain plasticity and neurological functional outcome after stroke. [Cell Transplant] Abstract

Ubiquitous High-Level Gene Expression in Hematopoietic Lineages Provides Effective Lentiviral Gene Therapy of Murine Wiskott-Aldrich Syndrome
Transplantation of stem cells transduced with MND-human Wiskott-Aldrich Syndrome protein (WASp) lentiviral vector resulted in sustained, endogenous levels of WASp in all hematopoietic lineages, progressive selection for WASp⁺ T, NKT and B cells, rescue of T cell proliferation and cytokine production, and substantial restoration of marginal zone B cells. [Blood] Abstract

Inflammation and TLR Ligation Differentially Affect the Osteogenic Potential of Human Mesenchymal Stromal Cells (MSC) Depending on Their Tissue Origin
Investigators hypothesized that an inflammatory environment and/or TLR ligation could affect the MSC differentiation potential. MSC were isolated from bone marrow, adipose tissue and umbilical cord Wharton’s Jelly. [Tissue Eng Part A] Abstract

Effect of Enamel Matrix Derivative and of Proline-Rich Synthetic Peptides on the Differentiation of Human Mesenchymal Stem Cells Toward the Osteogenic Lineage
The effect of artificial peptides, based on proline-rich domains of enamel matrix proteins, on the differentiation toward the osteogenic lineage of human umbilical cord mesenchymal stem cells was evaluated with or without osteogenic supplements and compared to the effect of the commercially available enamel matrix derivative. [Tissue Eng Part A] Abstract

Inhibitory Effect of Non-Anticoagulant Heparin on Pancreatic Cancer Cell Adhesion and Metastasis in Human Umbilical Cord Vessel Segment and in Mouse Model
Researchers’ aim was to investigate the effect of platelets on human pancreatic cancer MPanc96 cell adhesion to the endothelial cell vessel wall, and to examine the effect of heparin derivatives on MPanc96 adhesion using a novel, in vitro model of human umbilical cord vein. [Clin Exp Metastasis] Abstract

Unrelated Cord Blood Transplantation in Adult and Pediatric Acute Lymphoblastic Leukemia: Effect of Minimal Residual Disease on Relapse and Survival
Scientists’ data suggests that in acute lymphoblastic leukemia, achieving an minimal residual disease negative state pre-umbilical cord blood transplant improves outcomes. [Biol Blood Marrow Transplant] Abstract

Systematic Investigation of Oxygen and Growth Factors in Clinically Valid Ex Vivo Expansion of Cord Blood CD34⁺ Hematopoietic Progenitor Cells
Researchers performed the first study to characterize systematically the effect of growth factor combinations across multiple oxygen levels on the ex vivo expansion of cord blood CD34⁺ hematopoietic cells utilizing clinically approvable reagents and methodologies throughout. [Cytotherapy] Abstract

Ex Vivo Expansion of Cord Blood Progenitors Impairs Their Short-Term and Long-Term Repopulating Activity Associated with Transcriptional Dysregulation of Signaling Networks
In a xenograft transplantation model scientists showed that repopulating activity of cord blood cells declined following expansion. [Cell Prolif] Abstract

Glucose-Stimulated Insulin Secretion of Various Mesenchymal Stem Cells after Insulin-Producing Cell Differentiation
Researchers compared the growth potency of four kinds of mesenchymal stem cells derived from bone marrow, Wharton’s jelly, adipose tissue, and the periosteum. [J Biosci Bioeng] Abstract

Oncology Professionals and Leaders Honored for Contributions in the Progress Against Cancer
A former Surgeon General of the United States and leading researcher in leukemia in adults are among the notable awardees set to be honored by the American Society of Clinical Oncology at its 2012 Annual Meeting. [American Society of Clinical Oncology] Press Release

STEMSOFT: Here to Stay
STEMSOFT Software, the leading provider of blood and marrow transplant software solutions, is pleased to continue their dedication to serving the blood and marrow transplant community. [STEMSOFT Software Inc.] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the cord blood community.

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Stem Cell Technician (Kelly Scientific Resources)

Medical Technologist II – Cellular Therapy (San Diego Blood Bank)


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