Proteomic Cornerstones of Hematopoietic Stem Cell Differentiation: Distinct Signatures of Multipotent Progenitors and Myeloid Committed Cells Scientists applied an in-depth quantitative proteomic approach to analyze and compare the full proteomes of ex vivo isolated and FACS-sorted populations highly enriched for either multipotent hematopoietic stem/progenitor cells or myeloid committed precursors. [Mol Cell Proteomics] Abstract Prenatally Engineered Autologous Amniotic Fluid Stem Cell-Based Heart Valves in the Fetal Circulation The presented study investigates the fetal implantation of prenatally engineered living autologous cell-based heart valves. [Biomaterials] Abstract Histone Deacetylase 3 (HDAC-3) Modulates the Expansion of Human Hematopoietic Stem Cells Investigators have identified the valproic acid target HDAC3 as a negative regulator of umbilical cord blood hematopoietic stem cell expansion. [Stem Cells Dev] Abstract Protein Segregation Between Dividing Hematopoietic Progenitor Cells in the Determination of the Symmetry/Asymmetry of Cell Division Scientists investigated how the symmetry/asymmetry of cell division in mitotic CD34+ cells can be evaluated by determining the plane of cell division and the potential distribution of proteins between daughter cells. [Stem Cells Dev] Abstract In Search for Cross-Reactivity to Immunophenotype Equine Mesenchymal Stromal Cells by Multicolor Flow Cytometry Umbilical cord blood-derived undifferentiated equine mesenchymal stem cells of the fourth passage of six horses were characterized using multicolor flow cytometry based on the selected nine-marker panel of both cell surface antigens and intracytoplasmatic proteins. [Cytometry A] Abstract Insulin-Like Growth Factor Binding Protein-2 and Neurotrophin 3 Synergize Together to Promote the Expansion of Hematopoietic Cells Ex Vivo To determine whether neurotrophin-3 and insulin-like growth factor binding protein-2 are partly responsible for the growth promoting potential of mesenchymal stem cells, researchers investigated their impact on the growth and differentiation of umbilical cord blood-CD34+ cells. [Cytokine] Abstract Survival of Cord Blood Hematopoietic Stem Cells in a Hyaluronan Hydrogel for Ex Vivo Biomimicry The hyaluronic acid scaffold has been used for the first time to maintain long-term cultures of CD34+ hematopoietic cells obtained from human cord blood. [J Tissue Eng Regen Med] Abstract Neuroprotective Effects of Human Umbilical Cord Mesenchymal Stromal Cells in an Immunocompetent Animal Model of Parkinson’s Disease Scientists evaluated whether the transplantation of human mesenchymal stromal cells obtained from umbilical cord had a neuroprotective effect in a not-immunosuppressed rat Parkinson’s disease model. [J Neuroimmunol] Abstract |