Cord Blood News Volume 4.15 | Apr 19 2012

Ex Vivo Expansion of Hematopoietic Stem/Progenitor Cells from Human Umbilical Cord Blood on Acellular Scaffolds Prepared from MS-5 Stromal Cell Line
Acellular matrices were used as biological scaffolds for the lineage-specific expansion of magnetically sorted CD34⁺ cells and the results were evaluated by flow cytometry and colony-forming assays. [J Tissue Eng Regen Med] Abstract

Impact of Storage Temperature and Processing Delays on Cord Blood Quality: Discrepancy between Functional In Vitro and In Vivo Assays
Researchers evaluated the impact of preprocessing storage and temperature on recovery, viability, and functional differentiation capacities of hematopoietic progenitor cells. [Transfusion] Abstract

Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplant Grafts Using Oncolytic Myxoma Virus
Investigators demonstrated that ex vivo treatment with an oncolytic poxvirus called myxoma virus results in specific elimination of human myeloma cells by inducing rapid cellular apoptosis while fully sparing normal hematopoietic stem and progenitor cells. [Biol Blood Marrow Transplant] Abstract

Oxygen Tension Modifies the ‘Stemness’ of Human Cord Blood-Derived Stem Cells
Scientists investigated the effects of oxygen tension on the generation, proliferation and expression of stem cell marker genes, which could be critical during large-scale cell culture for clinical applications. [Cytotherapy] Abstract

Deferasirox Exposure Induces Reactive Oxygen Species and Reduces Growth and Viability of Myelodysplastic Hematopoietic Progenitors
The authors observed progressive, dose-dependent suppression of MDS progenitor proliferation in culture with deferasirox concentrations ranging from 5 μM to 20 μM. This effect was more pronounced in MDS compared to CD34+ progenitors isolated from umbilical cord blood or normal peripheral blood. [Leuk Res] Abstract

Male Gender Promotes an Increased Inflammatory Response to Lipopolysaccharide (LPS) in Umbilical Vein Blood
Researchers found that blood of male fetuses mounts a larger pro-inflammatory response to LPS. [J Matern Fetal Neonatal Med] Abstract

Preeclampsia Serum Upregulates CD40/CD40L Expression and Induces Apoptosis in Human Umbilical Cord Endothelial Cells
Researchers investigated the role of CD40/CD40L in the pathogenesis of preeclampsia (PE) by comparing the effect of maternal serum obtained from healthy pregnant women and PE patients on HUVEC cell growth, apoptosis and CD40/CD40L expression. [Reprod Biol Endocrinol] Abstract

Osteogenic Potential of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Cultured with Umbilical Cord Blood-Derived Autoserum
Researchers used autoserum derived from the umbilical cord blood of neonates in an attempt to examine the osteoblastic differentiation potential of umbilical cord-derived mesenchymal stromal cells in nude mice. [J Craniomaxillofac Surg] Abstract

Cook Group Forms Cook General BioTechnology, LLC
As part of its ongoing commitment to patients needing emerging new cellular therapies, Cook Group has acquired the assets of General BioTechnology LLC and launched a new company, Cook General BioTechnology LLC. [Cook Medical] Press Release

Stem Cell Agency Unveils Strategic Partnership Fund to Increase Investment and Engagement with Industry in Stem Cell Therapies for Patients
The California Institute for Regenerative Medicine (CIRM) is committing up to $30 million to a Strategic Partnership Awards Initiative to attract industry engagement and investment in CIRM-funded stem cell research. [California Institute for Regenerative Medicine] Press Release

VistaGen Licenses Breakthrough Stem Cell Culture Technology to Speed Development of Drug Screening and Cell Therapy for Immune System Disorders
VistaGen Therapeutics, Inc. has licensed breakthrough stem cell culture technology from the McEwen Centre for Regenerative Medicine located at the University Health Network in Toronto, Canada. [VistaGen Therapeutics, Inc.] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the cord blood community.

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Development Scientist – Cell Therapy (GE Healthcare)

Group Leaders, Principle Scientists – Stem Cell Clinical Product R&D (Shanghai Hengrui Pharmaceuticals Co., Ltd)


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