Impact of Pre-Transplant Minimal Residual Disease after Cord Blood Transplantation for Childhood Acute Lymphoblastic Leukemia in Remission. An Eurocord, PDWP-EBMT Analysis To address the prognostic value of minimal residual disease before unrelated cord blood transplantation in children with acute lymphoblastic leukemia (ALL), researchers analyzed 170 ALL children transplanted in complete remission after myeloablative conditioning regimen. [Leukemia] Abstract Mild Hyperthermia Promotes and Accelerates the Development and Maturation of Erythroid Cells Investigators hypothesized that Mild Hyperthermia (MH) could impact the differentiation of hematopoietic progenitors into erythrocytes and their subsequent maturation. Cell growth and erythroid differentiation increased dramatically in cord blood CD34+ cell cultures incubated under MH. [Stem Cells Dev] Abstract Transplantation of Cord Blood Mesenchymal Stem Cells as Spheroids Enhances Vascularization Researchers investigated whether the angiogenic efficacy of cord blood mononuclear cells can be enhanced by grafting as spheroids in a mouse hindlimb ischemia model. [Tissue Eng Part A] Abstract Umbilical Cord Blood-Derived Stromal Cells Regulate Megakaryocytic Proliferation and Migration through SDF-1/PECAM-1 Pathway The authors demonstrated that human umbilical cord blood-derived stromal cells secreted stromal cell derived factor-1 (SDF-1) to stimulate platelet endothelial cell adhesion molecule-1 (PECAM-1) expression in HEL cells, and consequently promoted the proliferation and migration of HEL cells. [Cell Biochem Biophys] Abstract Human Cord Blood CD133+ Cells Exacerbate Ischemic Acute Kidney Injury in Mice Data indicates that human cord blood-derived CD133+ cells unexpectedly exacerbate ischemic acute kidney injury in mice, possibly through soluble factors. [Nephrol Dial Transplant] Abstract The Secretome of Stem Cells Isolated from the Adipose Tissue and Wharton’s Jelly Acts Differently on Central Nervous System-Derived Cell Populations Researchers aimed to determine if stromal/stem cells isolated from the adipose tissue and umbilical cord preferentially act, or not, on specific cell populations within the central nervous system. [Stem Cell Res Ther] Abstract Validation of Human Monoclonal HLA Class I Antibodies to Evaluate the Kinetics of Donor Chimerism in Different Cell Subsets after Double-Cord-Blood Transplantation in the NOD/SCID Model Scientists conducted studies in a mouse model to develop a new analytic method using anti-human HLA Class I allele-specific monoclonal antibodies in flow cytometry. Single-cord-blood transplantation or double-cord-blood transplantation from HLA-mismatched donors was performed in NOD/SCID mice. [Transfusion] Abstract Cord-Blood Hematopoietic Stem-Cell Transplantation Confers an Increased Risk for Human Herpesvirus-6-Associated Acute Limbic Encephalitis: A Cohort Analysis Researchers found that patients receiving unrelated cord-blood transplantation have increased risk for post-transplantation acute limbic encephalitis and greater morbidity from this disease. [Biol Blood Marrow Transplant] Abstract Isolation and Characterization of Wharton’s Jelly Derived Multipotent Mesenchymal Stromal Cells Obtained from Bovine Umbilical Cord and Maintained in a Defined Serum-Free Three-Dimensional System The authors described for the first time the isolation and characterization of bovine-derived umbilical cord Wharton’s jelly cells in a serum free condition and maintenance of primitive mesenchymal phenotype. [BMC Biotechnol] Abstract Stem Cell-Based Photodynamic Therapy Investigators have used gaussia luciferase containing supernatant from culturing neural stem cells to perform in vitro photodynamic therapy of murine melanoma cells, and rat umbilical cord matrix-derived stem cells to perform in vivo PDT of lung melanomas in C57BL/6 mice. [Photochem Photobiol Sci] Abstract |