Cord Blood News Volume 4.19 | May 17 2012

Promotion of the Induction of Cell Pluripotency through Metabolic Remodeling by Thyroid Hormone Triiodothyronine-Activated PI3K/AKT Signal Pathway
To facilitate pluripotent reprogramming, researchers have identified the thyroid hormone triiodothyronine as an endogenous factor that can enhance reprogramming of human dermal fibroblasts and umbilical cord mesenchymal stem cells. [Biomaterials] Abstract

Biofunctionalized Calcium Phosphate Cement to Enhance the Attachment and Osteodifferentiation of Stem Cells Released from Fast-Degradable Alginate-Fibrin Microbeads
The authors aimed to construct alginate-fibrin microbeads encapsulating human umbilical cord mesenchymal stem cells embedded in the surface of novel biofunctionalized calcium phosphate cement (CPC) and investigate microbead degradation, cell release, and osteodifferentiation on CPC. [Tissue Eng Part A] Abstract

Human B-Cell Ontogeny in Humanized NOD/SCID γc^null Mice Generates a Diverse yet Auto/Poly- and HIV-1-Reactive Antibody Repertoire
Single human B cells were sorted from bone marrow and periphery of humanized NOD/SCID γc^null mice at eight to ten months post engraftment with human cord blood-derived CD34⁺ stem cells. [Genes Immun] Abstract

Symptomatic Generalized Epilepsy after HHV6 Posttransplant Acute Limbic Encephalitis in Children
Researchers report three children with human herpesvirus 6 (HHV6)-associated posttransplant acute limbic encephalitis 20-23 days after cord blood transplantation for leukemias who developed symptomatic generalized epilepsy. [Epilepsia] Abstract

Effect of Culture Media on Expansion Properties of Human Umbilical Cord Matrix-Derived Mesenchymal Cells
Because of the lack of a uniform approach to human umbilical cord matrix-derived mesenchymal (hUCM) cell expansion, scientists attempted to identify the optimum conditions for the production of a high quantity of hUCM cells by comparing two media. [Cytotherapy] Abstract

In Vivo Hepatic Differentiation of Mesenchymal Stem Cells from Human Umbilical Cord Blood after Transplantation into Mice with Liver Injury
The authors found that mesenchymal stem cells from human umbilical cord blood (hUCB) exhibit the potential to differentiate into hepatocyte-like cells in the livers of hUCB-transplanted mice as well as partially repair the liver damage induced by D-galactosamine/lipopolysaccharide. [Biochem Biophys Res Commun] Abstract

Early Recovery of Immunity after Cord-Blood Transplantation in Children: Qualitative Features and Impact of Cytomegalovirus Infection
Researchers investigated immune recovery and the effect of cytomegalovirus infection on the early stages of T-lymphocyte recovery after cord-blood transplantation from unrelated donors to 24 children. [Acta Haematol] Abstract

A New, Rapid and Reproducible Method to Obtain High Quality Endothelium In Vitro
The authors report a simple, flexible, fast and reproducible method for an efficient isolation of viable human umbilical vein endothelial cells (HUVECs). In addition, they describe how to culture HUVECs as valid cobblestone cells in vitro on different types of extracellular matrix. [Cytotechnology] Abstract

Compassionate Use of Pluristem’s PLX Cells Saves the Life of a Child after Bone Marrow Transplantation Failure
Pluristem Therapeutics, Inc. announced that a seven year-old girl suffering from an aplastic bone marrow whose condition was rapidly deteriorating is now experiencing a reversal of her condition with a significant increase in her red cells, white cells and platelets following the intramuscular injection of the company’s PLacental eXpanded (PLX) cells. [Pluristem Therapeutics, Inc.] Press Release

Research Investment in Bone Marrow Failure Disease
Two research projects focused on a bone marrow failure disease recently received funding from the Aplastic Anemia and Myelodysplasia Association of Canada and the Canadian Institutes of Health Research. [Canadian Institutes of Health Research] Press Release

A Global Standard for Peer Review
After winning the strong backing of the White House, Subra Suresh convened a meeting of 47 leaders of research funding agencies from 44 countries. At the conclusion of closed-door sessions, the group will issue the first-ever global statement on the principles of merit review. [National Science Foundation, United States] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the cord blood community.

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Business Development Manager – Stem Cell (SynGen Inc.)

Controller (SynGen Inc.)

Director: Regulatory Affairs (SynGen Inc.)

Manufacturing Manager (SynGen Inc.)

Development Scientist – Cell Therapy (GE Healthcare)

Group Leaders, Principle Scientists – Stem Cell Clinical Product R&D (Shanghai Hengrui Pharmaceuticals Co., Ltd)


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