MiR-181a Regulates MSCs Growth and Immune Function: MicroRNA-181a Regulates Local Immune Balance by Inhibiting Proliferation and Immunosuppressive Properties of Mesenchymal Stem Cells Investigators evaluated if and how microRNA (miR)-181a regulates mesenchymal stem cell (MSC) proliferation and immunosuppressive properties. They found that the expression of miR-181a in the MSCs derived from the umbilical cord and decidua of preeclampsia patients increased relative to MSCs derived from normal patients. [Stem Cells] Abstract Fast-Degradable Microbeads Encapsulating Human Umbilical Cord Stem Cells in Alginate for Muscle Tissue Engineering Compared to the usual method of seeding cells in a hydrogel matrix, the human umbilical cord mesenchymal stem cell-microbead-alginate matrix construct had greatly improved cell viability and myogenic differentiation, and hence is promising to enhance muscle regeneration. [Tissue Eng Part A] Abstract 2D Polymer-Based Cultures Expand Cord Blood-Derived Hematopoietic Stem Cells and Support Engraftment of NSG Mice Researchers focused on identifying promising two dimensional (2D) polymer candidates for hematopoietic stem cell expansion. After a seven day culture period with cytokine supplementation, 2D fibrin, poly(D,L-lactic-co-glycolic acid) and poly(ε-caprolactone) substrates supported expansion of cord blood-derived CD34+ cells ex vivo. [Tissue Eng Part C Methods] Abstract Thalidomide Has Anti-Inflammatory Properties in Neonatal Immune Cells Scientists evaluated the effects of thalidomide on the cytokine response and apoptosis of neonatal immune cells. After whole blood culture and stimulation of cord and adult blood samples, the intracytoplasmic expression and the secreted amounts of IL-2, TNF-α, IFN-γ, IL-6, IL-10 and IL-8 were assessed by flow cytometry and Cytokine Bead Array. [Innate Immun] Abstract The Fate of Renal Allografts Hinges on Responses of the Microvascular Endothelium Researchers evaluated the renal microvascular endothelial cell responses following exposure to preformed antibodies against human leukocyte antigens (HLA) in the recipient. They used cultured human umbilical cord vein endothelial cells, human microvascular glomerular endothelial cells, activated with and without IFN-γ and TNF-α, and pre-transplant blood group O patient sera containing multispecific HLA class I and class II antibodies. [Exp Mol Pathol] Abstract Inhibition of Erythropoiesis by Smad6 in Human Cord Blood Hematopoietic Stem Cells The authors showed that Smad6 inhibits erythropoiesis in human CD34+ cord blood hematopoietic stem cells. [Biochem Biophys Res Commun] Abstract Characterization and Comparison of Embryonic Stem Cell-Derived KDR+ Cells with Endothelial Cells Endothelial cells were induced from human embryonic stem cell lines and their biological characteristics were analyzed and compared with both cord blood endothelial progenitor cells and human umbilical vein endothelial cells in vitro. [Microvasc Res] Abstract Effects of Different Serum-Levels of Anti-Thymocyte Globulin after Unrelated Donor Umbilical Cord Blood Transplantation Low serum-levels of rabbit-IgG early after transplantation seem to be a strong predictor for acute GvHD grades III-IV, TRM and a low incidence of relapse in patients treated with thymoglobulin before unrelated donor umbilical cord blood transplantation. [Transpl Immunol] Abstract |