Ex Vivo Expansion of Normal and Chronic Myeloid Leukemic Stem Cells without Functional Alteration Using a NUP98HOXA10homeodomain Fusion Gene Researchers compared the number of long-term culture-initiating cells present in cultures of lenti-NUP98HOXA10homeodomain versus control virus-transduced CD34+ cells originally isolated from human cord blood and chronic phase chronic myeloid leukemia patients. [Leukemia] Abstract Cord Blood-Hematopoietic Stem Cell Expansion in Three-Dimensional Fibrin Scaffolds with Stromal Support Four different three-dimensional biomaterial scaffolds were tested for freshly isolated cord blood-CD34+ cell expansion in the presence of efficient exogenous cytokine supplementation and umbilical cord-mesenchymal stem cells. [Biomaterials] Abstract Dynamics of Human Prothymocytes and Xenogeneic Thymopoiesis in Hematopoietic Stem Cell-Engrafted Nonobese Diabetic-SCID/IL-2rγnull Mice To model the developmental pattern of human prothymocytes and thymopoiesis, researchers used NOD-scid/γc-/- mice grafted with human umbilical cord blood CD34+ hematopoietic progenitor cells. [J Immunol] Abstract Co-Transplantation of Ex Vivo Expanded Progenitors with Non-Expanded Cord Blood Cells Improves Platelet Recovery The authors found that human platelet recovery and short term bone marrow engraftment can be efficiently improved by the co-transplantation of megakaryocyte primed umbilical cord blood cells with non-expanded hematopoietic stem and progenitor cells in a murine transplantation model. [Stem Cells Dev] Abstract Mesoderm-Derived Stem Cells: The Link Between the Transcriptome and Their Differentiation Potential Researchers compared the global gene expression profiles of four mesoderm-derived stem cell populations: human adipose tissue-derived stromal cells, human bone marrow-derived stromal cells, human (fore)skin-derived precursor cells, and human Wharton's jelly-derived mesenchymal stem cells. [Stem Cells Dev] Abstract Glioma Stem Cell Invasion through Regulation of the Interconnected ERK, Integrin α6 and N-Cadherin Signaling Pathway Results demonstrated the dynamic interplay among extracellular signal-regulated kinase (ERK), N-cadherin and integrin α6 in glioma stem cell (GSC) invasion and also revealed the therapeutic potential of human umbilical cord blood stem cells in treating the molecular crosstalk observed in GSC-regulated invasion. [Cell Signal] Abstract Neuroglial Activation and Cx43 Expression Are Reduced Upon Transplantation of Human Umbilical Cord Blood Cells After Perinatal Hypoxic-Ischemic Injury Scientists investigated glial responses like inflammation and astrocytic activation in a rat model of neonatal hypoxic-ischemic brain injury and characterized changes of these parameters upon transplantation of human umbilical cord blood cells. [Brain Res] Abstract A Non-Rotational, Computer-Controlled Suspension Bioreactor for Expansion of Umbilical Cord Blood Mononuclear Cells The proliferation and differentiation characteristics of umbilical cord blood mononuclear cells were examined in a non-rotational suspension bioreactor with a fishtail mixer. [Biotechnol Lett] Abstract |