Amniotic-Fluid-Derived Mesenchymal Stem Cells Overexpressing Interleukin-1 Receptor Antagonist Improve Fulminant Hepatic Failure Researchers showed that amniotic-fluid-derived mesenchymal stem cells genetically modified to over-express interleukin-1-receptor antagonist can be implanted into the injured liver to provide a novel therapeutic approach to the treatment of fulminant hepatic failure. [PLoS One] Full Article In Vitro Endothelialization of Electrospun Terpolymer Scaffolds: Evaluation of Scaffold Type and Cell Source A family of methacrylic terpolymer biomaterials was electrospun into three-dimensional scaffolds. Three different endothelial-like cell populations were seeded onto the scaffolds under static conditions: human umbilical vein endothelial cells, adult human blood-derived outgrowth endothelial cells, and umbilical cord blood-derived human blood outgrowth endothelial cells. Researchers observed difference in cellular behavior based on both cell type and scaffold topography. [Tissue Eng Part A] Abstract Comparative In Vitro Analysis of Different Hematopoietic Cell Populations from Human Cord Blood: In Search of the Best Option for Clinically Oriented Ex Vivo Cell Expansion Investigators obtained different hematopoietic cell populations from umbilical cord blood and simultaneously assessed their proliferation and expansion kinetics. Their main goal was to determine which one of these cell populations would be more suitable for clinical-grade ex vivo expansion. [Transfusion] Abstract Interactions of Monocyte Subpopulations Generated from Cord Blood CD34+ Hematopoietic Progenitors with Tumor Cells: Assessment of Antitumor Potential Monocytes and their subsets generated from cord blood CD34+ progenitor cells were used for determination of their capacity to interact with tumor cells in vitro and in vivo. [Exp Hematol] Abstract CD26 Protease Inhibition Improves Functional Response of Un-Fractionated Cord Blood, Bone Marrow, and Mobilized Peripheral Blood Cells to CXCL12/SDF-1 Researchers observed that although cord blood (CB) had greater CD26 expression than bone marrow or mobilized peripheral blood (mobPB), treatment with a CD26 inhibitor resulted in increased responsiveness to SDF-1 for all three MNC sources tested. This suggests that clinical therapeutic benefit may be gained by utilizing CD26 inhibitors as a strategy to improve engraftment of un-fractionated mobPB cells as well as CB cells. [Exp Hematol] Abstract Growth and Differentiation Characteristics of Equine Mesenchymal Stromal Cells Derived from Different Sources Investigators compared clinically relevant characteristics of mesenchymal stromal cells derived from bone marrow, umbilical cord blood and tissue and from adipose tissue and tendon. Cell yield, proliferation, migration, tendon marker expression and differentiation into adipocytes, chondrocytes and osteoblasts was assessed, quantified and compared. [Vet J] Abstract Increased Reticulocyte Count from Cord Blood Samples Using Hypotonic Lysis Scientists describe a simple and inexpensive method to increase the reticulocyte count of cord blood samples. [Exp Parasitol] Abstract Superior Osteogenic Capacity of Different Mesenchymal Stem Cells for Bone Tissue Engineering Results suggested that human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and human adipose tissue-derived mesenchymal stem cells could be used for bone tissue engineering effectively; hUC-MSCs could serve as a new alternative cell source. [Oral Surg Oral Med Oral Pathol Oral Radiol] Abstract |