HLA-C-Dependent Prevention of Leukemia Relapse by Donor Activating KIR2DS1 Researchers assessed clinical data, HLA genotyping results, and donor cell lines or genomic DNA for 1277 patients with acute myeloid leukemia who had received hematopoietic stem-cell transplants from unrelated donors matched for HLA-A, B, C, DR, and DQ or with a single mismatch. [N Engl J Med] Abstract Kruppel Like Factor 7 Overexpression Suppresses Hematopoietic Stem and Progenitor Cell Function Results suggest that Kruppel like factor 7 is not required for normal hematopoietic stem and progenitor function, but increased expression, as seen in a subset of lymphoid leukemia, inhibits myeloid cell proliferation and promotes early thymocyte survival. [Blood] Abstract CADASIL Mutations and shRNA Silencing of NOTCH3 Affect Actin Organization in Cultured Vascular Smooth Muscle Cells Researchers analyzed NOTCH3 expression and morphology of actin cytoskeleton in genetically genuine cultured human cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) vascular smooth muscle cells (VSMCs) derived from different organs, and in control VSMCs with short hairpin RNA (shRNA)-silenced NOTCH3. [J Cereb Blood Flow Metab] Full Article Vitamin D Improves the Angiogenic Properties of Endothelial Progenitor Cells Endothelial colony forming cells (ECFCs) were obtained and cultured from cord blood, and characterized by immunocytochemistry and flow cytometry. Proliferation, total length of tubule formation on Matrigel, expression of VEGF mRNA and proMMP-2 activity were assessed after treatment of ECFCs with vitamin D3. [Am J Physiol Cell Physiol] Abstract SALL4 Is a Key Transcription Regulator in Normal Human Hematopoiesis Investigators found that SALL4 is a key regulator in normal human hematopoiesis and the mechanism of its function is at least in part through the HOXA9. Future study will determine whether modulating the SALL4/HOXA9 pathway can be used in cellular therapy such as cord blood expansion and/or myeloid engraftment. [Transfusion] Abstract Differential Expression of HSP90α and Heme Oxygenase in Cord Blood RBC during Preeclampsia Researchers analyzed the regulation relationship between HSP90α and HO-2 in cord blood RBC during preeclampsia. [Toxicol Mech Methods] Abstract |