Expression of Integrin A2 Receptor in Human Cord Blood Cd34+Cd38-Cd90+ Stem Cells Engrafting Long-Term in Nod/Scid-Il2rγCNull Mice Scientists report that primitive cord blood CD34+CD38-CD90+ stem cells, with the ability to reconstitute NOD/SCID-IL2Rγcnull mice long term, at 24 weeks after transplantation, can be prospectively isolated at an increased purity by using integrin α2 receptor as an additional stem cell marker. [Stem Cells] Abstract Late Outgrowth Endothelial Cells Resemble Mature Endothelial Cells and Are Not Derived from Bone Marrow Investigators aimed to identify the source and precursor of endothelial outgrowth cells (EOC) and to assess their regenerative potential compared to mature endothelial cells. EOC are readily isolated from umbilical cord blood (6/6 donors) and peripheral blood mononuclear cells (4/6 donors), but not from bone marrow (0/6) nor peripheral blood following mobilization with granulocyte-colony stimulating factor (0/6 donors). [Stem Cells] Abstract MicroRNA-140 Expression during Chondrogenic Differentiation of Equine Cord Blood-Derived Mesenchymal Stromal Cells Scientists investigated the expression of microRNA-140 during chondrogenic differentiation of equine cord blood derived mesenchymal stromal cells. [Stem Cells Dev] Abstract Cord Blood-Derived Mesenchymal Stromal Cells Down-Modulate CD4+ T-Cell Activation by Inducing IL-10 Producing Th1 Cells Investigators showed by a combination of PCR array, flow cytometry and multiplex cytokine data analysis that during the inhibition of an alloantigen-driven CD4+ T-cell response, mesenchymal stromal cells induce a fraction of CD4+ T-cells to co-express IFNγ and IL-10. [Stem Cells Dev] Abstract Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Promote Vascular Growth In Vivo Researchers examined the acquisition of properties associated with vascular growth by human umbilical cord blood-derived mesenchymal stem cells, and whether they promoted vascular growth in vivo. [PLoS One] Full Article Adhesion of Endothelial Cells and Endothelial Progenitor Cells on Peptide Linked Polymers in Shear Flow The initial adhesion of human umbilical vein endothelial cells, cord blood endothelial colony forming cells and human blood outgrowth endothelial cells was studied under radial flow conditions. [Tissue Eng Part A] Abstract Factors with an Impact on Chimerism Development and Long-Term Survival after Umbilical Cord Blood Transplantation The authors performed a retrospective single-center analysis of 50 umbilical cord blood transplantations (UCBTs), including 37 single and 13 double UCBTs. [Transplantation] Abstract | Video Long Term Effects of the Implantation of Wharton’s Jelly-Derived Mesenchymal Stem Cells from the Umbilical Cord for Newly-Onset Type 1 Diabetes Mellitus Researchers assessed the long-term effects of the implantation of Wharton’s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset Type 1 Diabetes Mellitus. [Endocr J] Abstract | Full Article The Antitumor Effect of Human Cord Blood-Derived Dendritic Cells Modified by the Livin α Gene in Lung Cancer Cell Lines Researchers used umbilical cord blood-derived dendritic cells infected with a recombinant adenovirus encoding the livin gene as a vaccine to activate effector cells such as cytotoxic T lymphocytes to recognize and kill livin-expressing cancer cells in vitro as an improved strategy for overcoming the ability of these cancer cells to escape apoptosis and antitumor immune responses. [Oncol Rep] Abstract |