| PUBLICATIONS (Ranked by impact factor of the journal) | MLL-AF9 Mediated Immortalization of Human Hematopoietic Cells Along Different Lineages Changes during Ontogeny Researchers showed that depending on extrinsic cues, human neonatal CD34+ cells are readily immortalized along either the myeloid or lymphoid lineage upon MLL-AF9 expression and give rise to mainly lymphoid leukemia in immunocompromised mice. In contrast, immortalization of adult bone marrow CD34+ cells is more difficult to achieve and is myeloid-biased, even when MLL-AF9 is expressed in purified hematopoietic stem cells. [Leukemia] Abstract Human Cord Blood γδ T Cells Expressing Public Vγ2 Chains Dominate the Response to Bisphosphonate Plus IL-15 Researchers report that in cord blood mononuclear cell cultures, a single round of stimulation, using aminobisphosphonates to elevate phosphoantigen levels, resulted in expansion of adult-like Vγ2 chains and accumulation of memory cells with cytotoxic potential. [Immunology] Abstract Increased Stem Cell Factor/c-kit by Hypoxia Promotes Autophagy of Human Placental Chorionic Plate-Derived Mesenchymal Stem Cells via Regulating the Phosphorylation of mTOR Researchers aimed to compare the effect of hypoxia on the self-renewal of bone marrow-derived mesenchymal stem cells (MSCs) and placental chorionic plate-derived mesenchymal stem cells and to investigate the regulatory mechanisms of self-renewal in each MSC type during hypoxia. [J Cell Biochem] Abstract Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells on Anterior Chamber-Associated Immune Deviation Researchers inoculated C57BL/6 mice with ovalbumin in the anterior chamber (AC) to induce anterior chamber-associated immune deviation, while a control group received AC injection of solvent alone. Immediately after the AC injection, the mice were injected through the tail vein with human umbilical cord-derived mesenchymal stem cells or phosphate buffer saline. All animals were subcutaneously immunized with ovalbumin one week later. Delayed-type hypersensitivity assay was performed another week following immunization. [Int Immunopharmacol] Abstract Human Umbilical Cord Mesenchymal Stem Cells Derived from Wharton’s Jelly Differentiate into Cholinergic-Like Neurons In Vitro Researchers examined whether Wharton’s jelly mesenchymal stem cells (WJ-MSCs) could differentiate into cholinergic-like neurons in vitro. After induction, the spindle-shaped or fibroblast-like WJ-MSCs changed into bulbous cells. The induced cells positively expressed cholinergic neuron’s markers, and an acetylcholine secretion of the induced WJ-MSCs was significantly elevated. [Neurosci Lett] Abstract Angiotensin-(1-7) Treatment Ameliorates Angiotensin II-Induced Apoptosis of Human Umbilical Vein Endothelial Cells Angiotensin (Ang)-(1-7), a metabolite of AngI and AngII, is a counter-regulatory mediator of AngII. Researchers investigated the effects of Ang-(1-7) on AngII-induced apoptosis in human umbilical vein endothelial cells. [Clin Exp Pharmacol Physiol] Abstract Immunosuppressive Properties of Mesenchymal Stromal Cells Derived from Amnion, Placenta, Wharton’s Jelly and Umbilical Cord Researchers aimed to explore the alternative sources of mesenchymal stem cells from amnion, placenta, Wharton’s jelly and umbilical cord, which are usually discarded. [Intern Med J] Abstract |
| INDUSTRY NEWS | Fate Therapeutics Initiates Phase II Clinical Study of ProHema for the Treatment of Hematologic Malignancies Fate Therapeutics, Inc. announced the initiation of a randomized, controlled, Phase II multi-center study of its investigational hematopoietic stem cell therapy, ProHema, in adult patients undergoing double umbilical cord blood transplantation for hematologic malignancy. [Fate Therapeutics, Inc.] Press Release Public Release of LifeMap Discovery™ Version 1.0 LifeMap Sciences, Inc. are pleased to announce the public release of LifeMap Discovery™ version 1.0. LifeMap Discovery is a state-of-the-art roadmap of embryonic development and stem cell biology. The platform integrates embryonic development and stem cell biology with molecular, cellular, anatomical and disease-related information, and provides data mining capabilities and bioinformatics applications. [LifeMap Sciences, Inc.] Press Release |
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