Interleukin-10 Controls the Protective Effects of Circulating Microparticles from Septic Shock Patients on Tissue-Engineered Vascular Media Scientists investigated the effects of septic microparticles on the contractile response of tissue-engineered vascular media (TEVM). TEVMs composed of only a media were produced by tissue engineering from human arterial smooth muscle cells isolated from umbilical cord. [Clin Sci] Abstract Direct Head-to-Head Comparison of Cationic Liposome-Mediated Gene Delivery to Mesenchymal Stem/Stromal Cells of Different Human Sources: A Comprehensive Study Investigators performed a comprehensive comparison of liposome-mediated gene transfer efficiencies to mesenchymal stem/stromal cells derived from different human sources – bone marrow, adipose tissue-derived cells and umbilical cord matrix. [Hum Gene Ther Methods] Abstract Pre-Engraftment Syndrome after Unrelated Cord Blood Transplantation: A Predictor of Engraftment and Acute Graft-versus-Host Disease Pre-engraftment syndrome (PES) is poorly characterized and its clinical significance and the prognostic impact after unrelated cord blood transplantation (CBT) are unclear. To address these issues, researchers analyzed retrospectively the incidence, risk factors and clinical outcomes of PES in unrelated CBT recipients. [Biol Blood Marrow Transplant] Abstract Toll-Like Receptor Mediated Eosinophil-Basophil Differentiation: Autocrine Signaling by GM-CSF in Cord Blood Hematopoietic Progenitors Since they have previously demonstrated that cord blood progenitors induce eosinophil/basophil (Eo/B) colony forming units after lipopolysaccharide (LPS) stimulation, the authors sought to investigate the intracellular mechanisms by which LPS induces Eo/B differentiation. [Immunology] Abstract Novel Alginate Three-Dimensional Static and Rotating Culture Systems for Effective Ex Vivo Amplification of Human Cord Blood Hematopoietic Stem Cells and In Vivo Functional Analysis of Amplified Cells in NOD/SCID Mice The authors investigated two novel three-dimensional culture systems (static and rotating) for ex vivo expansion of hematopoietic stem cells from umbilical cord blood. [Transfusion] Abstract Stem Cell Transplantation after Reduced Intensity Conditioning for Sickle Cell Disease In order to reduce transplant associated late effects, the feasibility of a highly immunosuppressive reduced intensity conditioning regimen was explored in children with sickle cell disease (SCD) and a matched sibling donor. Eight patients and symptomatic SCD were included. The conditioning regimen consisted of fludarabine, melphalan and either thiotepa or total lymphoid irradiation plus ATG or alemtuzumab. The graft was bone marrow in seven and cord blood in one case. [Eur J Haematol] Abstract Adenovector-Mediated Gene Delivery to Human Umbilical Cord Mesenchymal Stromal Cells Induces Inner Ear Cell Phenotype Investigators evaluated the potential of human umbilical cord mesenchymal stromal cells (hUCMSCs) as a possible source for regenerating inner ear hair cells. The expression of Atoh1 induced the differentiation of hUCMSCs into cells that resembled inner ear hair cells morphologically and immunocytochemically, evidenced by the expression of hair cell-specific markers. [Cell Reprogram] Abstract Sphingosine-1-Phosphate Induces VEGF-C Expression through a MMP-2/FGF-1/FGFR-1-Dependent Pathway in Endothelial Cells In Vitro Researchers investigated whether sphingosine-1-phosphate, a potent angiogenic factor, induced vascular endothelial growth factor-C (VEGF-C) expression in endothelial cells in vitro and examined its underlying mechanisms. Human umbilical vein endothelial cells were examined. [Acta Pharmacol Sin] Full Article |