Cord Blood News Volume 5.17 | May 2 2013

Methods of Freezing Cord Blood Hematopoietic Stem Cells
The authors compared the effect of two-step cryopreservation and controlled-rate freezing method on the post-thaw quality of cord blood (CB) and evaluated the post-thaw quality of hematopoietic stem cell fractions isolated from CB with various methods and frozen with controlled-rate freezing method. [Transfusion] Abstract

The Characteristic Expression Pattern of BMI-1 and SALL4 Genes in Placenta Tissue and Cord Blood
SALL4 and BMI-1 are important factors in hematopoiesis. Placental tissue (PT) and umbilical cord blood (CB) are rich in hematopoietic stem/progenitor cells, but their SALL4 and BMI-1 expression levels remain unknown. Real-time PCR was used to determine the expression level of these genes in PT and CB from ten cases, and ten healthy donors were used as control. [Stem Cell Res Ther] Abstract | Full Article

Exosomes Released by Human Umbilical Cord Mesenchymal Stem Cells Protect against Cisplatin-Induced Renal Oxidative Stress and Apoptosis In Vivo and In Vitro
Researchers focused on the protective effect of exosomes derived from human umbilical cord mesenchymal stem cells on cisplatin-induced nephrotoxicity in vivo and in vitro. [Stem Cell Res Ther] Abstract | Full Article

Comparative Evaluation of In Vivo Osteogenic Differentiation of Fetal and Adult Mesenchymal Stem Cell in Rat Critical-Sized Femoral Defect Model
Scientists compared the in vivo osteogenic potential of adult mesenchymal stem cells (MSCs) from adipose tissue and bone marrow with fetal MSCs from umbilical cord and umbilical cord blood by using a rat critical-sized femoral defect model. [Cell Tissue Res] Abstract

Conditioned Medium from Human Amniotic Epithelial Cells May Induce the Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells into Dopaminergic Neuron-Like Cells
Dopaminergic neuron therapy has been established as a new clinical tool for treating Parkinson's disease. Prior to cell transplantation, there are two primary issues that must be resolved: one is the appropriate seed cell origin, and the other is the efficient inducing technique. Human umbilical cord blood-derived mesenchymal stem cells were used as the available seed cells, and conditioned medium from human amniotic epithelial cells was used as the inducing reagent. [J Neurosci Res] Abstract

Umbilical Cord Blood Cells Regulate Endogenous Neural Stem Cell Proliferation via Hedgehog Signaling in Hypoxic-Ischemic Neonatal Rats
Investigators examined whether umbilical cord blood mononuclear cells promote neural stem cell proliferation via the Sonic hedgehog signaling pathway. [Brain Res] Abstract

Role of CD271 Enrichment in the Isolation of Mesenchymal Stromal Cells from Umbilical Cord Blood
Isolation of mesenchymal stromal cells (MSCs) from the umbilical cord blood (UCB) has a success rate of 25% and is frequently contaminated by osteoclast-like cells. CD271 is a well-known marker for the enrichment of bone marrow MSCs. Researchers assessed the effect of CD271 isolation on the isolation rate of MSCs from UCB. [Cell Biol Int] Abstract

Pluripotent Possibilities: Human Umbilical Cord Blood Cell Treatment after Neonatal Brain Injury
The pluripotent capacity of stem cells from the human umbilical cord blood provides simultaneous targeting of multiple neuropathologic events initiated by a hypoxic-ischemic insult. Their high regenerative potential and naïve immunologic phenotype makes them a preferable choice for transplantation. [Pediatr Neurol] Abstract

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STEMCELL Technologies Inc. Obtains License from iPS Academia Japan for Induced Pluripotent Stem Cell Technologies
STEMCELL Technologies Inc. has signed an agreement to license iPS Academia Japan’s induced pluripotent stem cell (iPS cell) technologies. This agreement will enable STEMCELL Technologies to develop media that are optimized for cellular reprogramming, further expanding its extensive portfolio of products designed to facilitate cutting-edge pluripotent stem cell research. [STEMCELL Technologies Inc.] Press Release

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NEW Postdoctoral Research Scientist (Anthony Nolan)

Research Associate (University of Texas Southwestern Medical Center at Dallas)

Postdoctoral Position - Novel Gene Discovery (St. Jude Children’s Research Hospital)

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Postdoctoral Position - Stem Cell Biology (St. Jude Children's Research Hospital)

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