Mouse Extra-Embryonic Arterial Vessels Harbor Precursors Capable of Maturing into Definitive HSCs Investigators showed that umbilical cord and vitelline arteries, but not veins, contain pre-hematopoietic stem cells (HSCs) capable of maturing into definitive HSCs in the presence of exogenous IL3, although in fewer numbers than the aorta-gonad-mesonephros region, and that pre-HSC activity in vitelline arteries increases with proximity to the embryo proper. The functional data strongly suggest that extra-embryonic arteries can actively contribute into adult hematopoiesis. [Blood] Abstract The Combined Influence of Substrate Elasticity and Surface-Grafted Molecules on the Ex Vivo Expansion of Hematopoietic Stem and Progenitor Cells Umbilical cord blood (UCB) is an attractive source of hematopoietic stem and progenitor cells (HSPCs) for transplantation. However, the low number of HSPCs from a single UCB donor limits the direct transplantation of UCB to patients. Because little is known about the effects of the physical microenvironment on HSPC expansion, researchers investigated the ex vivo expansion of HSPCs cultured on biomaterials with different elasticities and grafted with different nanosegments. [Biomaterials] Abstract Grafts Enriched with Subamnion-Cord-Lining Mesenchymal Stem Cell Angiogenic Spheroids Induce Post-Ischemic Myocardial Re-Vascularization and Preserve Cardiac Function in Failing Rat Hearts A crucial question in post-ischemic cell therapy refers to the ideal method of cell delivery to the heart. The authors hypothesized that epicardial implantation of subamnion-cord-lining mesenchymal stem cells angiogenic spheroids embedded within fibrin grafts facilitates donor cell survival and enhances cardiac function in failing rat hearts. [Stem Cells Dev] Abstract Impact of Graft-versus-Host Disease Prophylaxis on Outcomes after Myeloablative Single-Unit Umbilical Cord Blood Transplantation Myeloablative single-unit umbilical cord blood transplantation using busulfan, thiotepa, fludarabine and ATG resulted in high rates of engraftment and high anti-tumor activity. Researchers designed a new graft-versus-host disease prophylaxis, substituting long-term steroids by mycophenolate mofetil together with a slight reduction of ATG. [Biol Blood Marrow Transplant] Abstract The Effects of Hedgehog on RNA Binding Protein Msi1 during the Osteogenic Differentiation of Human Cord Blood-Derived Mesenchymal Stem Cells Scientists evaluated the direct effects of hedgehog (Hh) signaling on the osteogenic differentiation of human umbilical cord blood-derived mesenchymal stem cells and investigated potential downstream regulatory mechanisms responsible for Hh signaling. [Bone] Abstract Factors Affecting Umbilical Cord Blood Stem Cell Suitability for Transplantation in an In Utero Collection Program Researchers examined maternal, neonatal, and obstetric factors that influence the suitability for banking and transplantation of umbilical cord blood units collected in utero. [Transfusion] Abstract A Pilot Study of Umbilical Cord-Derived Mesenchymal Stem Cell Transfusion in Patients with Primary Biliary Cirrhosis Scientists investigated the safety and efficacy of umbilical cord-derived mesenchymal stem cell transfusion in primary biliary cirrhosis patients with an incomplete response to ursodeoxycholic acid. [J Gastroenterol Hepatol] Abstract | Full Article Biologic Properties of Gadolinium Diethylenetriaminepentaacetic Acid-Labeled and PKH26-Labeled Human Umbilical Cord Mesenchymal Stromal Cells Investigators aimed to characterize gadolinium diethylenetriaminepentaacetic acid-labeled and PKH26-labeled human umbilical cord mesenchymal stromal cells and to track them with magnetic resonance imaging in vitro and in vivo. [Cytotherapy] Abstract |