Cord Blood News Volume 5.31 | Aug 8 2013

PIMT Prevents the Apoptosis of Endothelial Cells in Response to Glycated Low Density Lipoproteins and Protective Effects of Grape Seed Procyanidin B2
The authors hypothesized that Protein L-isoaspartyl methyltransferase (PIMT) plays a critical role in glycated low density lipoproteins (gly-LDL) induced vascular endothelial cell (VEC) apoptosis and that grape seed procyanidin B2 protects against gly-LDL induced VEC apoptosis through PIMT regulation. [PLoS One]
Full Article

A Truncated Flt1 Isoform that Activates Src and Promotes Invasion in Breast Cancer Cells Is Upregulated by Notch-1 and Notch-3 and Downregulated by miR-200c and Retinoic Acid
Scientists report that the expression of isoform transcribed from intron 21 Flt1 in HUVEC and MDA-MB-231 cells is downregulated by the γ-secretase inhibitor DAPT. [J Cell Biochem] Abstract

Vascular Endothelial Cell Injury Partly Induced by Mesenteric Lymph in Heat Stroke
Mesenteric lymph, collected pre-, during, and post-heat stroke, was analyzed for biological activity on human umbilical vein endothelial cell in vitro. [Inflammation] Abstract

Human Unrestricted Somatic Stem Cell Administration Fails to Protect Nude Mice from Cisplatin-Induced Acute Kidney Injury
In spite of beneficial effects on other disease models, the renoprotective potential of human cord blood-derived unrestricted somatic stem cells (USSC) has not been examined so far. Acute kidney failure was induced in female nude mice and the effect of USSC transplantation on kidney function and structure was assessed. [Nephron Exp Nephrol] Abstract

Wharton’s Jelly-Derived Mesenchymal Stem Cells Promote Myocardial Regeneration and Cardiac Repair after Miniswine Acute Myocardial Infarction
Researchers investigated the therapeutic effects of Wharton’s jelly-derived mesenchymal stem cells on myocardial regeneration and cardiac repair after acute myocardial infarction. [Coron Artery Dis] Abstract

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LifeCell International Set to Cut Stem Cell Banking Rates by 60%
LifeCell International will be slashing its banking prices by 50 to 60 per cent in a few months. The company, which had secured private equity funds recently, will try to expand its market by lowering the pricing. [Financial Chronicle] Press Release

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Postdoctoral Research Associates – Stem Cell Biology (University of Illinois at Chicago)

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Postdoctoral Researcher – Hematopoietic Stem Cells (Albert Einstein College of Medicine)

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