Generation of Functional, Antigen-Specific CD8+ Human T Cells from Cord-Blood Stem Cells Using Exogenous Notch and Tetramer-TCR Signaling Researchers showed that human umbilical cord blood-derived CD34+CD38-/low hematopoietic stem cells can be successfully differentiated into functional, antigen-specific cytotoxic CD8+ T cells without direct stromal co-culture or retroviral T cell receptor (TCR) transfection. [Stem Cells] Abstract Alternative Donor Hematopoietic Stem Cell Transplantation for Mature Lymphoid Malignancies after Reduced-Intensity Conditioning Regimen: Similar Outcomes with Umbilical Cord Blood and Unrelated Donor Peripheral Blood The authors studied 645 adult patients with mature lymphoid malignancies who received an allogeneic unrelated donor transplant using umbilical cord blood or mobilized peripheral blood stem cells after a reduced-intensity conditioning regimen. [Haematologica] Abstract The Single-Nucleotide Polymorphism (GPX4c718t) in the Glutathione Peroxidase 4 Gene Influences Endothelial Cell Function: Interaction with Selenium and Fatty Acids Human umbilical vein endothelial cells and monocytes homozygous for the T- or C-variant of the GPX4c718t single nucleotide polymorphism were assessed for monocyte-endothelial cell adhesion, expression of VCAM-1 and sensitivity to oxidative challenge. [Mol Nutr Food Res] Full Article Adipogenic Potential in Human Mesenchymal Stem Cells Strictly Depends on Adult or Fetal Tissue Harvest Scientists compared the adipogenic potential of mesenchymal stem cells originated from two adult sources as fat pads and bone marrow, and from four fetal sources as umbilical cord blood, Wharton’s jelly, amniotic fluid and preterm umbilical cord perivascular cells. [Int J Biochem Cell Biol] Abstract Immunologic Recovery in Children after Alternative Donor Allogeneic Transplantation for Hematologic Malignancies: Comparison of Recipients of Partially T-Cell Depleted Peripheral Blood Stem Cells and Umbilical Cord Blood Investigators compared immunologic recovery in children undergoing hematopoietic stem cell transplantation for hematologic malignancies receiving either T-cell depletion of peripheral blood stem cells or umbilical cord blood over a seven year period at a single institution. [Biol Blood Marrow Transplant] Abstract Intravitreal Transplantation of Human Umbilical Cord Blood Stem Cells Protects Rats from Traumatic Optic Neuropathy Researchers treated traumatic optic neuropathy with transplantation of human umbilical cord blood stem cells and explored how transplanted stem cells participate in the neuron repairing process. [PLoS One] Full Article Evaluation of Potential Ionizing Irradiation Protectors and Mitigators Using Clonogenic Survival of Human Umbilical Cord Blood Hematopoietic Progenitor Cells Scientists evaluated the use of colony formation by human umbilical cord blood hematopoietic progenitor cells for testing novel small molecule ionizing irradiation protectors and mitigators. [Exp Hematol] Abstract The Anti-Apoptotic and Neuro-Protective Effects of Human Umbilical Cord Blood Mesenchymal Stem Cells (hUCB-MSCs) on Acute Optic Nerve Injury Is Transient Researchers transplanted mesenchymal stem cells derived from human umbilical cord blood into the vitreous cavity of adult rats and investigated the probable capacity of anti-apoptosis and pro-neuroprotective effects on retinal ganglion cells. [Brain Res] Abstract Intravenous Administration of Human Umbilical Cord Blood-Derived AC133+ Endothelial Progenitor Cells in Rat Stroke Model Reduces Infarct Volume: Magnetic Resonance Imaging and Histological Findings Previous studies have indicated that stem/progenitor cells derived from human umbilical cord blood (hUCB) improve functional recovery in stroke models. Researchers examined the effect of hUCB AC133+ endothelial progenitor cells on stroke development and resolution in a middle cerebral artery occlusion rat model. [Stem Cells Transl Med] Abstract | Press Release |