Curculigoside Improves Osteogenesis of Human Amniotic Fluid Derived Stem Cells Scientists evaluated the effect of curculigoside on osteogenic differentiation of human amniotic fluid derived stem cells (hAFSCs). The results showed that curculigoside stimulated alkaline phosphatase activity and calcium deposition of hAFSCs during osteogenic differentiation in a dose-dependent manner (1-100 μg/mL) while the effects were reduced at the higher concentration of 200 μg/mL. [Stem Cells Dev] Abstract Expansion of Donor-Reactive Host T Cells in Primary Graft Failure after Allogeneic Hematopoietic SCT Following Reduced-Intensity Conditioning Scientists evaluated if the expansion of host T cells could be associated with graft rejection after reduced-intensity conditioning cord blood transplantation (RIC-CBT). Expansion of residual host lymphocytes was observed in four out of seven patients with graft rejection at 3 weeks after CBT, but in none of the 17 patients who achieved engraftment. [Bone Marrow Transplant] Abstract Blockade by Phosphorothioate Aptamers of Advanced Glycation End Products-Induced Damage in Cultured Pericytes and Endothelial Cells Researchers screened novel phosphorothioate-modified aptamers directed against advanced glycation end products (AGEs) (AGEs-thioaptamers) using a combinatorial chemistry in vitro, and examined whether these aptamers could inhibit the AGE-induced damage in both retinal pericytes and human umbilical vein endothelial cells. [Microvasc Res] Abstract Induction of Human Umbilical Wharton’s Jelly-Derived Stem Cells toward Oligodendrocyte Phenotype The authors examined phenotypic features of human Wharton’s jelly mesenchymal stem cells (WJMSCs)-derived oligodendrocytes (OLs). They induced human WJMSCs to form OLs by signaling molecules including basic fibroblastic growth factor, platelet-derived growth factor-AA, and triiodothyronine hormone. [J Mol Neurosci] Abstract Human Amniotic Fluid Stem Cells Have a Potential to Recover Ovarian Function in Mice with Chemotherapy-Induced Sterility The ability of human amniotic fluid cells (hAFCs) to differentiate into germ cell and oocyte-like cells has been previously documented. In this study, researchers report the potential use of hAFCs to help restore follicles in clinical condition involving premature ovarian failure. [BMC Dev Biol] Full Article Comparative Analysis of Human Mesenchymal Stem Cells from Bone Marrow, Adipose Tissue, and Umbilical Cord Blood as Sources of Cell Therapy To characterize mesenchymal stem cells (MSCs) from different sources, investigators compared human bone marrow, adipose tissue, and umbilical cord blood-derived MSCs for surface antigen expression, differentiation ability, proliferation capacity, clonality, tolerance for aging, and paracrine activity. [Int J Mol Sci] Abstract | Full Article CREG Promotes the Proliferation of Human Umbilical Vein Endothelial Cells through the ERK/Cyclin E Signaling Pathway Researchers attempted to investigate the effect of cellular repressor of E1A-stimulated genes (CREG) on the proliferation of vascular endothelial cells and to decipher the underlying molecular mechanisms. Overexpression of CREG in human umbilical vein endothelial cells was obtained by infection with adenovirus carrying CREG. [Int J Mol Sci] Abstract | Full Article |