Cord Blood News Volume 5.41 | Oct 17 2013

A Xeno-Free Culture Method that Enhances Wharton’s Jelly Mesenchymal Stromal Cell Culture Efficiency over Traditional Animal Serum-Supplemented Cultures
Scientists demonstrated for the first time that human serum from umbilical cord blood is an effective co-culture reagent for mesenchymal stromal cell (MSC) production from Wharton’s jelly MSCs. [Cytotherapy] Abstract

Human Umbilical Cord Mesenchymal Stem Cells Inhibit C6 Glioma Growth via Secretion of Dickkopf-1 (DKK1)
Researchers demonstrated that human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) inhibited C6 cell growth and modulated the cell cycle to G0/G1 phase. The expression of β-catenin and c-Myc was downregulated in C6 cells by conditioned media (CM) from hUC-MSCs, and the levels of secreted DKK1 were positively correlated with concentrations of hUCMSCs-CM. [Mol Cell Biochem] Abstract

A Comparative Study on Culture Conditions and Routine Expansion of Amniotic Fluid-Derived Mesenchymal Progenitor Cells
Scientists determined the best out of three published expansion protocols for mesenchymal progenitors in terms of self-renewal ability. Characterization was performed based on morphology, surface marker analysis, cytogenetic stability, and differentiation potential. [Fetal Diagn Ther] Abstract

Comparison of Different Methods for the Isolation of Mesenchymal Stem Cells from Umbilical Cord Matrix: Proliferation and Multilineage Differentiation as Compared to Mesenchymal Stem Cells from Umbilical Cord Blood and Bone Marrow
Investigators identified the most appropriate method of isolating human umbilical cord matrix-derived mesenchymal stem cells (UCM-MSCs) and compared morphological, phenotypic, proliferative, and differentiation characteristics of UCM-MSCs with bone marrow-derived MSCs and umbilical cord blood-derived MSCs. [Cell Biol Int] Abstract

Promoting Effects of Heparin on Ex Vivo Expansion of Megakaryocytopoiesis from Human Cord Blood CD34+ Cells
Scientists investigated the effects of heparin on ex vivo colony forming unit-megakaryocytes and megakaryocytes expansion from cord blood CD34+ cells. [Transfus Med Hemoth] Full Article

Prospective Surface Marker-Based Isolation and Expansion of Fetal Endothelial Colony-Forming Cells from Human Term Placenta
Investigators isolated clinically relevant quantities of fetal endothelial colony-forming cells (ECFCs) from human term placenta and compared them to the well-established donor-matched umbilical cord blood-derived ECFCs. [Stem Cells Transl Med] Abstract

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New York Stem Cell Foundation Announces $10.5 Million to Seven New NYSCF-Robertson Investigators
The New York Stem Cell Foundation (NYSCF) named seven of the most promising scientists as its 2013 NYSCF – Robertson Investigators. Each Investigator will receive a $1.5 million award, which will be disbursed over the next five years, which will enable them to expand their laboratories and train other scientists. [The New York Stem Cell Foundation] Press Release

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Translational Clinician-Scientist – Stem Cell Transplantation (Boston Children’s Hospital)

Postdoctoral Position – Patient-Specific Stem Cell Lines: Disease Modeling, Repair and Transplantation (Columbia University)

Postdoctoral Position – Cellular and Genetic Therapies for Hemoglobinopathies (Blood Systems Research Institute)

Postdoctoral Position – Immune Recovery after Hematopoietic Stem Cell Transplantation (University of Minnesota – Twin Cities)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Fellow – Differentiation of Erythrocytes and Endothelial Cells from Hemangioblast (University of Rochester)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

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