Modeling the Sitagliptin Effect on Dipeptidyl Peptidase-4 Activity in Adults with Hematological Malignancies After Umbilical Cord Blood Hematopoietic Cell Transplantation This clinical study included 24 patients who received myeloablative conditioning followed by oral sitagliptin with single-unit umbilical cord blood hematopoietic cell transplantation. Using a nonlinear mixed-effects approach, a semi-mechanistic pharmacokinetic-pharmacodynamic model was developed to describe dipeptidyl peptidase-4 activity from these trial data, using NONMEM version 7.2 software. [Clin Pharmacokinet] Abstract Effect of Mesenchymal Stem Cells and Extracts Derived from the Placenta on Trophoblast Invasion and Immune Responses Investigators analyzed the effects of chorionic plate-derived mesenchymal stem cells and human placenta extract isolated from human normal placentas on trophoblasts invasion and immune responses. [Stem Cells Dev] Abstract CD146+ Human Umbilical Cord Perivascular Cells Maintain Stemness under Hypoxia and as a Cell Source for Skeletal Regeneration Human umbilical cord perivascular cells (HUCPVCs) were isolated and sorted by CD146+ pericyte marker. The purified CD146+ HUCPVCs were induced to differentiate efficiently into osteoblast, chondrocyte and adipocyte lineages in vitro. [PLoS One] Full Article Mesenchymal Stem Cells from Umbilical Cord Matrix, Adipose Tissue and Bone Marrow Exhibit Different Capability to Suppress Peripheral Blood B, Natural Killer and T Cells Investigators evaluated the influence of human mesenchymal stem cells derived from umbilical cord matrix, bone marrow and adipose tissue, co-cultured with phytohemagglutinin-stimulated peripheral blood mononuclear cells, on T, B and natural killer (NK) cell activation; T and B cells’ ability to acquire lymphoblast characteristics; mRNA expression of interleukin-2, forkhead box P3, T-bet and GATA binding protein 3, on purified T cells, and tumor necrosis factor-alpha, perforin and granzyme B on purified NK cells. [Stem Cell Res Ther] Abstract | Full Article Combination of a Haploidentical SCT with an Unrelated Cord Blood Unit: A Single-Arm Prospective Study Scientists conducted a single-arm prospective study in 50 patients who received the combination of an haploidentical stem cell graft and an unrelated umbilical cord blood unit for the treatment of hematological malignancies. [Bone Marrow Transplant] Abstract Mesenchymal Stem Cell Isolation from Human Umbilical Cord Tissue: Understanding and Minimizing Variability in Cell Yield for Process Optimization Cell yield, growth, and differentiation potential of umbilical cord tissue extracted cells was analyzed from tissue processed by explant and enzymatic digestion. [Biopreserv Biobank] Abstract Detection of Cytokines in Supernatant from Hematopoietic Stem/Progenitor Cells Co-Cultured with Mesenchymal Stem Cells and Endothelial Progenitor Cells Researchers aimed to investigate the significance of cytokine expression in supernatant from hematopoietic stem/progenitor cells co-cultured with mesenchymal stem cells (MSCs) or endothelial progenitor cells (EPCs). Mononuclear cells were isolated from normal human umbilical cord blood and then cultured solely or co-cultured with MSCs or EPCs. [Cell Tissue Bank] Abstract |