Cord Blood News Volume 5.46 | Nov 21 2013

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    Cord Blood News 5.46 November 21, 2013

    Cord Blood News

         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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    TOP STORY
    Ligand-Independent FLT3 Activation Does Not Cooperate with MLL-AF4 to Immortalize/Transform Cord Blood CD34+ Cells
    Investigators explored whether FLT3.TKD mutation or increased expression of FLT3.WT cooperates with MLL-AF4 to immortalize/transform cord blood-CD34+ hematopoietic stem/progenitor cells. [Leukemia] Abstract
    New Cord Banking Software Solution from STEMSOFT

     
    PUBLICATIONS ( Ranked by impact factor of the journal)
    A Set of MicroRNAs Mediate Direct Conversion of Human Umbilical Cord Lining-Derived Mesenchymal Stem Cells into Hepatocytes
    Scientists aimed to clarify the instructive role of six overexpressed microRNAs (miRNAs) (miR-1246, miR-1290, miR-148a, miR-30a, miR-424 and miR-542-5p) during hepatic differentiation of human umbilical cord lining-derived mesenchymal stem cells (hMSCs) and to test whether overexpression of any of these miRNAs is sufficient to induce differentiation of the hMSCs into hepatocyte-like cells. [Cell Death Dis] Full Article

    Alveolar Macrophages Are Critical for the Inhibition of Allergic Asthma by Mesenchymal Stromal Cells
    Using a mouse model of allergic asthma, scientists showed that administration of mesenchymal stromal cells isolated from human bone marrow, umbilical cord, or adipose tissue provoked a pronounced increase in alveolar macrophages and inhibited hallmark features of asthma, including airway hyperresponsiveness, eosinophilic accumulation, and Th2 cytokine production. [J Immunol] Abstract

    Nanofiber-Expanded Human Umbilical Cord Blood-Derived CD34+ Cell Therapy Accelerates Murine Cutaneous Wound Closure by Attenuating Pro-Inflammatory Factors and Secreting IL-10
    Using an excision wound model in NOD/SCID mice, scientists showed that nanofiber-expanded human umbilical cord blood-derived-CD34+ cells home to the wound site and significantly accelerate the wound-healing process compared to vehicle-treated control. [Stem Cell Res] Abstract

    Storage Time Affects Umbilical Cord Blood Viability
    The impact of delayed cryopreservation for up to three days on the viability of both CD45+ and CD34+ cell populations in 28 cord blood (CB) donations with volumes of 58.40±15.4mL was investigated to establish whether precryopreservation storage time could be extended from the current time of 24 to 48 hours in line with other CB banks. [Transfusion] Abstract

    How Important Is Differentiation in the Therapeutic Effect of Mesenchymal Stromal Cells in Liver Disease?
    After hepatic differentiation of umbilical cord-derived mesenchymal stromal cells (MSCs) in vitro, scientists detected both MSC and hepatocyte-like cell expressions of adhesion molecules and chemokine receptor CXCR4 by flow cytometry; immunosuppressive potential and hepatocyte growth factor expression were determined by means of enzyme-linked immunosorbent assay. [Cytotherapy] Abstract

    Gestational Diabetes Induces Alterations in the Function of Neonatal Endothelial Colony Forming Cells
    Children born to mothers with gestational diabetes mellitus (GDM) experience increased risk of developing hypertension, type 2 diabetes mellitus, and obesity. Disrupted function of endothelial colony forming cells (ECFCs) may contribute to this enhanced risk. The goal of this study was to determine if cord blood ECFCs from GDM pregnancies exhibit altered functionality. [Pediatr Res] Abstract

    Effects of Octylphenol on the Expression of Cell Cycle-Related Genes and the Growth of Mesenchymal Stem Cells Derived from Human Umbilical Cord Blood
    Investigators isolated human mesenchymal stem cells (MSCs) from umbilical cord blood and demonstrate that cultured MSCs express the surface marker, CD34, but not CD105. [Int J Mol Med] Abstract

    Technical Bulletin: Assays For Cord Blood

     
    REVIEWS
    The Evolving Art of Hematopoietic Stem Cell Transplantation: Translational Research in Post-Transplant Immune Reconstitution and Immunosuppression
    The authors review studies of post-transplant immune recovery and approaches to achieve more selective immunosuppressive strategies. [Immunol Res] Abstract

    Visit our reviews page to see a complete list of reviews in the cord blood research field.

     
    INDUSTRY NEWS
    Kiadis Pharma Provides Positive Update on its Phase II Clinical Program with Blood Cancer Treatment ATIR™
    Kiadis Pharma B.V. announced the successful Phase II enrollment of approximately ten patients of whom the majority have already been transplanted and received ATIR™. [Kiadis Pharma B.V.] Press Release

    Phiten® and Professional Baseball Players Team Up with Be The Match® to Make More Cures Possible for Blood Cancer Patients
    Phiten and professional baseball players C.J. Wilson, Josh Hamilton and J.B. Shuck have teamed up with Be The Match, the nonprofit organization dedicated to helping patients with blood cancers receive life-saving bone marrow and umbilical cord blood transplants. [Phiten Technology] Press Release

    From our sponsor:
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    POLICY NEWS
    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)

    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

     
    EVENTS
    NEW 19th Congress of the European Hematology Association
    June 12-15, 2014
    Milan, Italy

    Visit our events page to see a complete list of events in the cord blood community.

     
    JOB OPPORTUNITIES
    NEW PhD Studentship – iNKT Cells to Prevent Graft versus Host Disease (University of Birmingham)

    Postdoctoral Associate – Graft-vs.-Host Disease and Graft-vs.-Leukemia in Mouse Models (Yale University School of Medicine)

    Clinical Researcher – Hematopoietic Stem Cell Transplant Program (Northwestern University- Feinberg School of Medicine)

    Postdoctoral Research Fellows – Isolation of Stem Cells from Placenta and Amniotic Fluid (Wake Forest Institute for Regenerative Medicine)

    Adult Stem Cell Transplant Physician (John Theurer Cancer Center)

    Postdoctoral Position – Human Pluripotent and Hematopoietic Stem Cell Bioinformatics (Albert Einstein College Medicine)

    Translational Clinician-Scientist – Stem Cell Transplantation (Boston Children’s Hospital)

    Postdoctoral Position – Patient-Specific Stem Cell Lines: Disease Modeling, Repair and Transplantation (Columbia University)

    Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

    Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

    Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)


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