The Structural Basis of Functional Improvement in Response to Human Umbilical Cord Blood Stem Cell Transplantation Researchers investigated the long-term effects of stem cell therapy on both myocardial fiber organization and regional contractile function using a rat model of post-infarct remodeling. Human non-hematopoietic umbilical cord blood stem cells were administered via tail vein to rats two days after infarct surgery. [Cell Transplant] Abstract Single-Unit Cord Blood Transplantation following G-CSF-Combined Myeloablative Conditioning for Myeloid Malignancies not in Remission Researchers report on the outcome of unrelated cord blood transplantation using a conditioning regimen of 12 Gy total body irradiation, granulocyte colony-stimulating factor (G-CSF)-combined high-dose cytarabine, and cyclophosphamide in 61 adult patients with acute myelogenous leukemia or advanced myelodysplastic syndrome not in remission. [Biol Blood Marrow Transplant] Abstract Malignant Transformation Potentials of Human Umbilical Cord Mesenchymal Stem Cells Both Spontaneously and via 3-Methycholanthrene Induction Investigators isolated human umbilical cord mesenchymal stem cells from ten donors and assessed their transformation potential either spontaneously or by treating them with 3-methycholanthrene, a DNA-damaging carcinogen. [PLoS One] Full Article A Novel Source of Cultured Podocytes Researchers report having established for the first time a stem-like cell population derived from human amniotic fluid and possessing characteristics of podocyte precursors. [PLoS One] Full Article MYOD Mediates Skeletal Myogenic Differentiation of Human Amniotic Fluid Stem Cells and Regeneration of Muscle Injury In order to induce myogenic differentiation of human amniotic fluid stem (hAFS) cells, lentiviruses for MYOD were constructed and transduced into hAFS cells. Formation of myotube-like cells was analyzed by immunocytochemistry, and expression of molecular markers for myoblasts was analyzed by reverse transcription polymerase chain reaction and Western blotting. [Stem Cell Res Ther] Abstract | Full Article Pulmonary Manifestations of the Pre-Engraftment Syndrome after Umbilical Cord Blood Transplantation Pre-engraftment syndrome (PES) is a condition occurring after umbilical cord blood transplantation characterized by fever and erythematous skin rash prior to neutrophil engraftment. Investigators sought to determine the incidence and characterize the pulmonary manifestations of PES. [Ann Hematol] Abstract Successful Unrelated Umbilical Cord Blood Transplantation for Class 3 β-Thalassemia Major Using a Reduced-Toxicity Regimen Scientists describe two patients who underwent successful unrelated umbilical cord blood transplant using a novel reduced-toxicity preparative regimen. This regimen may be sufficiently immunosuppressive and myeloablative to ensure engraftment with reduced risks of toxicity and mortality. [Pediatr Transplant] Abstract Regeneration of Full-Thickness Skin Defects Using Umbilical Cord Blood Stem Cells Loaded into Modified Porous Scaffolds Scientists demonstrated the ability of cord blood-derived unrestricted somatic stem cells and chitosan-modified poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffold to promote skin regeneration. [ASAIO J] Abstract |