Human Cytomegalovirus Infection Promotes Rapid Maturation of NK Cells Expressing Activating Killer Ig-Like Receptor in Patients Transplanted with NKG2C-/- Umbilical Cord Blood In view of the hypothesis that NKG2C could be directly involved in NK cell maturation driven by human CMV infection, investigators analyzed the maturation and function of NK cells developing in three patients with hematological malignancies given umbilical cord blood transplantation from donors carrying a homozygous deletion of the NKG2C gene. [J Immunol] Abstract Human Mesenchymal Stromal Cells from Adult and Neonatal Sources: A Comparative In Vitro Analysis of Their Immunosuppressive Properties against T Cells Investigators compared mesenchymal stromal cells from bone marrow, umbilical cord blood and placenta in terms of their immunosuppressive properties against lymphoid cell populations enriched for CD3+ T cells. [Stem Cells Dev] Abstract An Expanded Population of CD34+ Cells from Frozen Banked Umbilical Cord Blood Demonstrate Tissue Repair Mechanisms of Mesenchymal Stromal Cells and Circulating Angiogenic Cells in an Ischemic Hind Limb Model The authors reported that culturing CD34+/CD45+ blood cells from frozen umbilical cord blood units in a medium supplemented with FGF4, SCF and FLT3-ligand produced a population of cells that remain CD34+/CD45+ but have an increased capacity for tissue healing. [Stem Cell Rev] Abstract Towards an Advanced Therapy Medicinal Product Based on Mesenchymal Stromal Cells Isolated from the Umbilical Cord Tissue: Quality and Safety Data Investigators described the adaptation of a proprietary method for isolation of a specific umbilical cord tissue-derived population of mesenchymal stromal cells, herein designated by its registered trademark as UCX®, towards the production of an advanced therapy medicinal product. [Stem Cell Res Ther] Abstract | Full Article The Hollow Fiber Bioreactor as a Stroma-Supported, Serum-Free Ex Vivo Expansion Platform for Human Umbilical Cord Blood Cells Scientists developed a bio-mimetic co-culture platform using the hollow fiber bioreactor for ex vivo expansion of hematopoietic stem cells. [Biotechnol J] Abstract Effects of Intravenous Administration of Umbilical Cord Blood CD34+ Cells in a Mouse Model of Neonatal Stroke The intravenous administration of human umbilical cord blood CD34+ cells modestly reduced histological ischemic brain damage after neonatal stroke in mice, with a transient augmentation of cerebral blood flow in the peri-infarct area. [Neuroscience] Abstract Wharton’s Jelly Human Mesenchymal Stem Cell Contact Guidance by Noisy Nanotopographies Researchers studied Wharton’s jelly human mesenchymal stem cells interacting with nanogratings having a controlled amount of nanotopographical noise. They argue that highly anisotropic nanopatterned scaffolds can be successfully exploited to drive stem cell migration in regenerative medicine protocols and discuss the impact of scaffold alterations or wear. [Sci Rep] Full Article Gene Therapy of Ovarian Cancer Using IL-21-Secreting Human Umbilical Cord Mesenchymal Stem Cells in Nude Mice The authors investigated effect of human umbilical cord mesenchymal stem cells as vehicles for a constant source of transgenic interleukin-21 (IL-21) on ovarian cancer in vivo. [J Ovarian Res] Abstract | Full Article Effect of Human Wharton’s Jelly Mesenchymal Stem Cell Paracrine Signaling on Keloid Fibroblasts Researchers investigated paracrine signaling effects of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells on keloid fibroblasts in vitro. [Stem Cells Transl Med] Abstract |