Cord Blood News Volume 6.06 | Feb 20 2014

Characterization of Neutrophil Subsets in Healthy Human Pregnancies
Researchers analyzed the phenotype of low-density granulocytes and compared it to the phenotype of normal density granulocytes in maternal peripheral blood, placental biopsies and cord blood. [PLoS One] Full Article

Impact of Sex Incompatibility on the Outcome of Single-Unit Cord Blood Transplantation for Adult Patients with Hematological Malignancies
Donor-recipient sex incompatibility has been associated with transplant outcomes in allogeneic hematopoietic SCT. However, its effect on the outcome of cord blood transplantation (CBT) is yet to be clarified. Researchers retrospectively analyzed 191 adult patients who received single-unit CBT after myeloablative conditioning for malignant disease in our institute. [Bone Marrow Transplant] Abstract

Implication of Different Effector Mechanisms by Cord Blood-Derived and Peripheral Blood-Derived Cytokine-Induced Killer Cells to Kill Precursor B Acute Lymphoblastic Leukemia Cell Lines
Cord blood (CB) and peripheral blood (PB)-cytokine-induced killer (CIK) cells were differentiated. CD56⁺ CB- and PB-CIK cells were compared for expression of different phenotypic markers and for the lytic pathways used to kill B-cell acute lymphoblastic leukemia cell lines. [Cytotherapy] Abstract

Effective Expansion of Engrafted Human Hematopoietic Stem Cells in Bone Marrow of Mice Expressing Human Jagged-1
To prepare the relatively human bone marrow environment in mice, the authors generated non-obese diabetic/severe combined immunodeficiency/IL-2 receptor gamma chain null (NOG) mice expressing human Jagged1 (hJ1) in an osteoblast-specific manner (hJ1-NOG mice) to examine whether Notch signaling induced by hJ1 mediates hHSC proliferation and/or maintenance in mice. In the transplantation experiments of CD34⁺ cells obtained from human cord blood, CD34⁺CD38^– cells were more increased in hJ1-NOG recipient mice than in non-transgenic littermates in mouse bone marrow environment. [Exp Hematol] Abstract

IL-27 Improves Migrational and Antiviral Potential of CB Dendritic Cells
Scientists examined effects of interleukin (IL)-27 on monocyte derived dendritic cells (moDCs) to approach its particular role in the specialized immune system of the human neonate. Exogenous IL-27 promotes IL-27 transcription in cord blood (CB) and adult blood moDCs. [Hum Immunol] Abstract

Epstein-Barr Virus Induces the Differentiation of Semi-Mature Dendritic Cells from Cord Blood Monocytes
Researchers compared the effects of Epstein-Barr virus on cord blood (CB) and adult dendritic cells (DCs) differentiation and maturation including phenotype by flow cytometry, cytokine by ELISA and RT-PCR. They evaluated the function of DC by co-culture DC and regulatory T cells (Tregs) by detection the expression of Foxp3, the phenotype and the cytokine profile of Tregs by flow cytometry. [Hum Immunol] Abstract

Comparison of Human Mesenchymal Stem Cells Isolated by Explant Culture Method from Entire Umbilical Cord and Wharton’s Jelly Matrix
Investigators compared two simple and cost-effective explant culture methods for isolation of mesenchymal stem cells from human umbilical cord. [Cell Tissue Bank] Abstract

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STC Life Co., Ltd. Successfully Treats Patients with Parkinson’s Disease at Stem Cell Research and Treatment Center
Stem cell research institute of STC Life Co., Ltd. and 97.7 B&H Clinic successfully completed mesenchymal stem cell therapy for the patients with Parkinson’s disease. Mesenchymal stem cells, one of the adult stem cells, are used a lot for neogenesis, and the stem cell research institute of STC Life Co., Ltd. used stem cells separated from the umbilical cord of fetus. [Business Wire] Press Release

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NEW Postdoctoral Position – Hematopoietic Stem Cell Self-Renewal (University of Iowa)

Postdoctoral Associate – Hematopoietic Malignancies (University of Miami)

Director – Clinical Immunogenetics Laboratory (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Stem Cells (Imagine Institute)

Postdoctoral Position – Hematopoietic Stem Cell Biology (St. Jude Children’s Research Hospital)

Postdoctoral Positions – Hematopoietic Stem Cell Physiology and Bone Marrow Failure (University of Michigan)

Assistant Professorship – Hematopoietic Stem Cells and Microenvironment (University of Zurich)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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