Existence, Functional Impairment and Lung Repair Potential of Endothelial Colony Forming Cells in Oxygen-Induced Arrested Alveolar Growth Intra-jugular administration of human cord blood-derived endothelial colony forming cells after established arrested alveolar growth restored lung function, alveolar and lung vascular growth and attenuated pulmonary hypertension. [Circulation] Abstract Late Onset Colitis after Cord Blood Transplant Is Consistent with Graft-versus-Host Disease: Results of a Blinded Histopathological Review Scientists tested the hypothesis that recipients of umbilical cord blood transplantation had late-occurring colitis distinct from graft-versus-host disease and colitis in other allograft recipients. [Biol Blood Marrow Transplant] Abstract FOXP3 Is a Direct Target of miR15a/16 in Umbilical Cord Blood Regulatory T Cells Exact mechanism of action of umbilical cord blood (CB)-derived regulatory T cells (Tregs) in the prevention of GvHD remains unclear. On the basis of selective overexpression of peptidase inhibitor 16 in CB Tregs, researchers explored the related p53 pathway, which has been shown to negatively regulate miR15a/16 expression. [Bone Marrow Transplant] Abstract No Evidence of Clonal Dominance after Transplant of HOXB4-Expanded Cord Blood Cells in a Nonhuman Primate Model Researchers previously reported the development of leukemia in several nonhuman primate subjects transplanted with HOXB4-expanded bone marrow cells at approximately two years post-transplant. Here, they provide long-term data for a nonhuman primate receiving a HOXB4-expanded cord blood graft. [Exp Hematol] Abstract Mir-302 Cluster Exhibits Tumor Suppressor Properties on Human Unrestricted Somatic Stem Cells Previous reports have shown the participation of miR-302-367 cluster in cell cycle regulation of human embryonic stem cells, MCF7, HepG2, and Teta-2 embryonal teratocarcinoma cells, but its effect on unrestricted somatic stem cells as a new source of human somatic stem cells from the umbilical cord blood remains to be elucidated. Researchers investigated the effect of miR-302-367 cluster on cell proliferation by MTT assay, cell cycle analysis, and colony formation assay. [Tumor Biol] Abstract Mir-218 Contributes to the Transformation of 5-Aza/GF Induced Umbilical Cord Mesenchymal Stem Cells into Hematopoietic Cells through the MITF Pathway Researchers demonstrated that umbilical cord-derived human mesenchymal stem cells are easily accessible and could be induced into cells with hematopoietic function. Furthermore, they focused on the crucial miRNAs and relative transcription factors. [Mol Biol Rep] Abstract A Simple and Serum-Free Protocol for Cryopreservation of Human Umbilical Cord as Source of Wharton’s Jelly Mesenchymal Stem Cells Investigators optimized a serum-free formulation of 10% dimethyl sulfoxide and 0.2M sucrose for cryopreservation of umbilical cord tissue. [Cryobiology] Abstract Effects of Bone Marrow Mesenchymal Stem Cells on Hematopoietic Recovery and Acute Graft-versus-Host Disease in Murine Allogeneic Umbilical Cord Blood Transplantation Model Researchers investigated the effect of bone marrow mesenchymal stem cells on hematopoietic recovery and acute graft-versus-host disease in a murine allogeneic umbilical cord blood transplantation model. [Cell Biochem Biophys] Abstract |