Cord Blood News Volume 6.18 | May 15 2014

Endothelial Progenitor Cells Derived from Wharton’s Jelly of Human Umbilical Cord Attenuate Ischemic Acute Kidney Injury by Increasing Vascularization and Decreasing Apoptosis, Inflammation, and Fibrosis
Researchers examined the therapeutic potential of implantation of endothelial progenitor cells isolated from Wharton’s jelly of human umbilical cord in the treatment of renal ischemia/reperfusion injury in mice. [Cell Transplant] Full Article

Microvesicles Derived from Human Wharton’s Jelly Mesenchymal Stem Cells Promote Human Renal Cancer Cell Growth and Aggressiveness through Induction of Hepatocyte Growth Factor
In a previous study, microvesicles (MVs) released from human Wharton’s jelly mesenchymal stem cells retard the growth of bladder cancer cells. Researchers would like to know if MVs have a similar effect on human renal cell carcinoma (RCC). By use of cell culture and the BALB/c nu/nu mice xeno-graft model, the influence of MVs upon the growth and aggressiveness of RCC (786-0) was assessed. [PLoS One] Full Article

Human Amniotic Fluid Stem Cells: Neural Differentiation In Vitro and In Vivo
Scientists tested the neural differentiation potential of c-Kit⁺/Oct-4⁺ human amniotic fluid stem cells in vitro and their survival and integration in vivo. [Cell Tissue Res] Abstract

Changes in PTTG1 by Human TERT Gene Expression Modulate the Self-Renewal of Placenta-Derived Mesenchymal Stem Cells
Researchers aimed to generate immortalized MSCs derived from MSCs isolated from placenta (naive) by human TERT gene transfection with the AMAXA gene delivery system, to compare their characteristics, and to investigate whether increased TERT expression affected the pituitary tumor transforming gene (PTTG1; also known as securin), which is involved in chromosome segregation during mitosis. [Cell Tissue Res] Abstract

Human Cord Blood Stem Cell Paracrine Factors Activate the Survival Protein Kinase Akt and Inhibit Death Protein Kinases JNK and p38 in Injured Cardiomyocytes
Investigators hypothesized that paracrine factors from human umbilical cord blood mononuclear cells activate in injured cardiomyocytes the survival protein kinase Akt and limit activation of death protein kinases JNK and p38. [Cytotherapy] Abstract

Nicotine Promotes Late Endothelial Progenitor Cells Functional Activity in a Phosphatidylinositol 3-Kinase-Dependent Manner
Researchers investigated whether nicotine had influences on the functional activity of late endothelial progenitor cells (EPCs). Late EPCs were isolated from human umbilical cord blood and characterized. [Cell Biochem Biophys] Abstract

Amniotic Fluid-Derived Mesenchymal Stem Cells Prevent Fibrosis and Preserve Renal Function in a Preclinical Porcine Model of Kidney Transplantation
To determine the efficiency and the safety of amniotic fluid-derived mesenchymal stem cells (af-MSCs) infusion in a preclinical porcine model of renal autotransplantation, researchers injected autologous af-MSCs in the renal artery six days after transplantation. [Stem Cells Transl Med] Abstract

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STEMCELL Technologies Inc. Has Just Released NEW MesenCult™ Proliferation Kit with MesenPure™ (Mouse), a Novel Cell Culture Medium to Advance Research on Mouse Mesenchymal Stem and Progenitor Cells (MSCs)
MesenCult™ Proliferation Kit with MesenPure™ (Mouse) is a novel cell culture medium to advance research on mouse mesenchymal stem and progenitor cells (MSCs). [STEMCELL Technologies Inc.] Press Release

$4 Million from Eli and Edythe Broad Foundation Will Support UCLA Research
Two new gifts from The Eli and Edythe Broad Foundation to UCLA totaling $4 million will fund research in stem cell science and digestive diseases and support the recruitment of key faculty at two renowned research centers. [UCLA] Press Release

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Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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Postdoctoral Researcher – HLA and Non-HLA Genetic Markers in Hematopoietic Stem Cell Transplantation (NHS Blood and Transplant)

Research Associate – Hematopoietic Stem Cell Development (King’s College London)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (The Research Institute, Nationwide Children’s Hospital)

Assistant/Associate Professor – Blood Bank and Transfusion Medicine (University of Virginia Health System)

Postdoctoral Position – Hematopoiesis (Albany Medical Center)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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