Cord Blood News Volume 6.20 | May 29 2014

Acidic Preconditioning Improves the Proangiogenic Responses of Endothelial Colony Forming Cells
Considering that endothelial colony-forming cells (ECFC) are a subpopulation of CD34+ cells and key players in vasculogenesis, researchers investigated the effect of acidosis on the survival and functionality of ECFC. Endothelial colony-forming cells obtained by differentiation of human cord blood CD34+ cells in endothelial growth medium-2 for 14-21 days were exposed at pH 7.4, 7.0 or 6.6. [Angiogenesis] Abstract

Mismatched Related and Unrelated Donors for Allogeneic Hematopoietic Cell Transplantation for Adults with Hematologic Malignancies
Two parallel Phase II trials in adults with hematologic malignancies demonstrated comparable survival after reduced intensity conditioning and transplantation of either two HLA-mismatched umbilical cord blood units or bone marrow from HLA-haploidentical relatives. [Biol Blood Marrow Transplant] Abstract

Human Placenta Mesenchymal Stem Cells Expressing Exogenous Kringle1-5 Protein by Fiber-Modified Adenovirus Suppress Angiogenesis
Researchers report human placenta-derived mesenchymal stem cell-based gene therapy using a fiber-modified adenoviral vector carrying the kringle1-5 gene to maintain long-term survival and effectively suppress angiogenesis both in vitro and in vivo. [Cancer Gene Ther] Abstract

Osteogenic Differentiation of Umbilical Cord and Adipose Derived Stem Cells onto Highly Porous 45S5 Bioglass^®-Based Scaffolds
Investigations concerned the osteogenic cell attachment, growth and differentiation of adipose tissue derived mesenchymal stem cells (MSC) compared with MSC from human full term umbilical cord tissues on porous Bioglass^®-based scaffolds over a cultivation period of five weeks. [J Biomed Mater Res A] Abstract

Neonatal Monocytes Express Antiapoptotic Pattern of Bcl-2 Proteins and Show Diminished Apoptosis Upon Infection with Escherichia coli
mRNA and protein expression of B-cell lymphoma 2 (Bcl-2) family proteins in cord blood and adult peripheral blood monocytes infected with E. coli were analyzed by quantitative real-time PCR and flow cytometry, cytochrome c release by fluorescence microscopy. [Pediatr Res] Abstract

Combined Injection of Three Different Lineages of Early Differentiating Human Amniotic Fluid-Derived Cells Restores Urethral Sphincter Function in Urinary Incontinence
Researchers investigated whether a triple combination of early-differentiated cells derived from human amniotic fluid stem cells would show synergistic effects in urethral sphincter regeneration. [BJU Int] Abstract

Effect of Topology of Poly(L-Lactide-co-ε-Caprolactone) Scaffolds on the Response of Cultured Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells and Neuroblastoma Cell Lines
The effect of the surface topology and pore architecture were studied on the biocompatibility for supporting the growth of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells and human neuroblastoma cells as cell models. [J Biomater Sci Polym Ed] Abstract

Acute Funisitis Is Associated with Distinct Changes in Fetal Hematologic Profile
The hematologic profiles of umbilical cord blood obtained at birth were compared according to the presence or absence of acute funisitis in 197 preterm neonates (gestational age before 34 weeks) born to mothers with preterm labor with intact membranes or premature rupture of membranes. [J Matern Fetal Neonatal Med] Abstract

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Stem Cell Research on Campus Grows after $3 Million Boost
Cornell Stem Cell Program researchers Professor John Schimenti and Nikitin received $3 million from the New York State Stem Cell Science program of the New York State Department of Health to support the Stem Cell Modeling and Phenotyping Core. [Cornell University] Press Release

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Postdoctoral Fellow – Cell Therapy with Umbilical Mesenchymal Stem Cells (University of Cincinnati)

Postdoctoral Research Scientist – Immunotherapy (The Anthony Nolan Trust)

Associate Member – Translational Hematopoietic Cell Gene Therapy and Engineering (Fred Hutchinson Cancer Research Center)

Research Associate – Hematopoietic Stem Cell Development (King’s College London)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (The Research Institute, Nationwide Children’s Hospital)

Assistant/Associate Professor – Blood Bank and Transfusion Medicine (University of Virginia Health System)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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