Cord Blood News Volume 6.23 | Jun 19 2014

Gene Transfer Properties and Structural Modeling of Human Stem Cell-Derived AAV
Researchers reported for the first time, the presence of novel AAV variants in healthy CD34⁺ human peripheral blood stem cells. Gene transfer vectors derived from these novel AAVs efficiently underwent entry and post-entry processing in human cord blood stem cells and supported stable gene transfer into long-term, in vivo engrafting human HSCs significantly better than other serotypes. [Mol Ther] Abstract

B7 Costimulation and Intracellular Indoleamine 2,3-Dioxygenase (IDO) Expression in Umbilical Cord Blood and Adult Peripheral Blood
Scientists determined the frequency of activated (CD11b+) monocytes expressing B7-1, B7-2, B7-H1, and B7-H2, and that of T cells and CD4+ T helper cells expressing CD28, CTLA-4, PD-1, and ICOS in umbilical cord blood and adult peripheral blood samples using flow cytometry. [Biol Blood Marrow Transplant] Abstract

Unrelated Cord Blood Transplantation for Patients with Primary or Secondary Myelofibrosis
To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis, the authors evaluated 35 UCBT reported to Eurocord. [Biol Blood Marrow Transplant] Abstract

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells
Researchers described a method to generate a human blood brain barrier model using cord blood-derived hematopoietic stem cells. [PLoS One] Full Article

The Effect of Anticoagulant Choice on Collection of Cord Blood
The authors compared cord blood samples exposed to either lyophilized heparin or CPD during collection and a simulated transit period thereafter. [Transfusion] Abstract

Using Human Umbilical Cord Cells for Tissue Engineering: A Comparison with Skin Cells
Researchers placed epithelial cells and Wharton’s jelly cells from the umbilical cord in the context of a reconstructed skin substitute in combination with skin keratinocytes and fibroblasts. They compared the ability of the epithelial cells from both sources to generate a stratified, differentiated skin-like epithelium upon exposure to air when cultured on the two stromal cell types. [Differentiation] Abstract

Functional Characterization of Histamine H4 Receptor on Human Mast Cells
Investigators determined the expression of H4R in human mast cells (HMC-1, LAD-2 and primary cord blood derived CD34+ human mast cells) and characterized its functional properties. [Mol Immunol] Abstract

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Pluristem Granted Patent in Russia for Treatment of Inflammatory Bowel Disease Using Placenta-Derived Cells
Pluristem Therapeutics Inc. announced that Russia’s Federal Service for Intellectual Property has granted to Pluristem Patent No. 2515156 titled, “Methods of Treating Inflammatory Colon Diseases”. The patent covers methods for treating ulcerative colitis or Crohn’s disease using placenta-derived cells. This patent has already been issued to Pluristem in South Africa and is currently pending in several other jurisdictions. [Pluristem Therapeutics Inc.] Press Release

Pluristem Receives Patent in India for Cell Therapy Production Methods and Compositions
Pluristem Therapeutics Inc. announced it has been granted Patent No. 261087 from India’s Office of the Controller General of Patents, Designs & Trade Marks for a patent titled, “Methods for Cell Expansion and Conditioned Media Produced Thereby for Therapy.” [Pluristem Therapeutics Inc.] Press Release

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NEW Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

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Postdoctoral Position – Hematopoietic Stem Cell Research (UT Southwestern Medical Center at Dallas)

Postdoctoral Researcher – Novel PSC-Based Blood Therapeutics (Fred Hutchinson Cancer Research Center)

Research Associate – Hematology/Oncology (University of Chicago)

Postdoctoral Researcher – Hematopoietic Stem Cells & iPSCs (KU Leuven)

Postdoctoral Fellow – Cell Therapy with Umbilical Mesenchymal Stem Cells (University of Cincinnati)

Postdoctoral Research Scientist – Immunotherapy (The Anthony Nolan Trust)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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