Cord Blood News Volume 6.26 | Jul 10 2014

Molecular and Functional Analyses of Motor Neurons Generated from Human Cord Blood Derived Induced Pluripotent Stem Cells
Scientists present for the first time the differentiation of human cord blood derived induced pluripotent stem cells into motor neurons, the cell type primarily affected in amyotrophic lateral sclerosis. [Stem Cells Dev] Abstract

Umbilical Cord Mesenchymal Stem Cells Suppress Host Rejection: The Role of the Glycocalyx
Investigators aimed to determine the key components involved in the ability of the umbilical cord mesenchymal stem cells (UMSCs) to modulate the inflammatory system, and to identify the inflammatory cells that are regulated by the UMSCs. [J Biol Chem] Abstract | Full Article

Donor-Recipient Allele-Level HLA Matching of Unrelated Cord Blood Units Reveals High Degrees of Mismatch and Alters Graft Selection
Investigators analyzed the high-resolution donor-recipient HLA match of 100 double-unit 4-6/6 HLA-A,-B antigen, -DRB1 allele-matched cord blood grafts and their back-up units. [Bone Marrow Transplant] Abstract

Allogeneic Hematopoietic Cell Transplantation for Myelofibrosis Using Fludarabine-, Intravenous Busulfan- and Low-Dose TBI-Based Conditioning
Researchers report their institutional experience with 27 myelofibrosis patients who underwent hematopoietic cell transplantation using fludarabine-, intravenous BU- and low-dose total body irradiation-based reduced-intensity or full-intensity conditioning regimens. [Bone Marrow Transplant] Abstract

Impact of Recipient ABH Secretor Status on Outcome in Minor ABO-Incompatible Hematopoietic Stem Cell Transplantation
As ABH substances are expressed on tissues and secreted in body fluids, they could drive an immune response in minor ABO-incompatible hematopoietic stem cell transplantation. Researchers aimed to investigate the prognostic role of the recipients’ ABH secretor status. [Transfusion] Abstract

Non-Traditional CD4⁺CD25^–CD69⁺ Regulatory T Cells Are Correlated to Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
Non-traditional CD4⁺CD25^–CD69⁺ T cells were found to be involved in disease progression in tumor-bearing mouse models and cancer patients recently. Scientists attempted to define whether this subset of T cells was related to leukemia relapse after allogeneic hematopoietic cell transplantation. [J Transl Med] Full Article

Two-Way Regulation between Cells and Aligned Collagen Fibrils: Local 3D Matrix Formation and Accelerated Neural Differentiation of Human Decidua Parietalis Placental Stem Cells
Researchers report on the concerted changes of human decidua parietalis placental stem cells and the highly ordered collagen fibril matrix in response to cell-matrix interaction. [Biochem Biophys Res Commun] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

University of Pennsylvania’s Personalized Cellular Therapy for Leukemia Receives FDA’s Breakthrough Therapy Designation
A University of Pennsylvania-developed personalized immunotherapy has been awarded the U.S. Food and Drug Administration’s Breakthrough Therapy designation for the treatment of relapsed and refractory adult and pediatric acute lymphoblastic leukemia. The investigational therapy, known as CTL019, is the first personalized cellular therapy for the treatment of cancer to receive this classification. [Penn Medicine] Press Release

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Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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Postdoctoral Fellow – Intense Immunosuppression Followed by Autologous Hematopoietic Stem Cell Transplantation (University of Genoa)

Grant Writer – Pediatric Hematology, Oncology, Stem Cell Transplant, and Cancer Biology (Stanford University School of Medicine)

Cord Tissue Processing Technician (Cord Blood Registry)

Clinical HSCT Faculty Position (University of Wisconsin School of Medicine and Public Health)

Postdoctoral Position – Hematopoietic Stem Cell Research (UT Southwestern Medical Center at Dallas)

Research Associate – Hematology/Oncology (University of Chicago)

Postdoctoral Researcher – Hematopoietic Stem Cells & iPSCs (KU Leuven)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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