Asymmetric Aneuploidy in Mesenchymal Stromal Cells Detected by In Situ Karyotyping and Fluorescence In Situ Hybridization: Suggestions for Reference Values for Stem Cells Researchers investigated the frequency of cytogenetic aberrations in mesenchymal stromal cells (MSCs) using G-banding and fluorescence in situ hybridization and suggest reference values for aneuploidy in MSCs. Cytogenetic analysis was performed on 103 consecutive cultures from 68 MSCs (25 adipose-origin, 20 bone marrow-origin, 18 cord blood-origin, and five neural stem cells; eight from adipose tissue of patients with breast cancer and 60 from healthy donors). [Stem Cells Dev] Abstract Outcomes after Hematopoietic Stem Cell Transplant for Children with I-Cell Disease Although hematopoietic stem cell transplant (HSCT) has been used to successfully treat some lysosomal storage diseases, there have been only two case reports in the use of HSCT to treat mucolipidosis type II (MLII) or I-cell disease. Scientists describe the combined international experience in the use of HSCT for MLII in 22 patients. [Biol Blood Marrow Transplant] Abstract Effect of CD8+ Cell Content on Umbilical Cord Blood Transplantation in Adults with Hematological Malignancies This single center, cohorts study included patients with hematological malignancies who received umbilical cord blood transplantation after myeloablative conditioning regimen. [Biol Blood Marrow Transplant] Abstract Qualitative and Quantitative Comparison of the Proteome of Erythroid Cells Differentiated from Human iPSCs and Adult Erythroid Cells by Multiplex TMT Labelling and NanoLC-MS/MS The authors analyzed the proteome of erythroid cells differentiated from the induced pluripotent stem cells (iPSC) fibroblast derived line and showed they express hallmark red blood cell proteins, including all those of the ankyrin and 4.1R complex. They next compared the proteome of erythroid cells differentiated from three iPSC lines with that of adult and cord blood progenitors. [PLoS One] Full Article Outcome of Patients with HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma after SCT: A Retrospective Study by the EBMT LWP Experience with allo-SCT for adult T-cell leukemia/lymphoma (ATL) appears encouraging but is limited to Japanese series. Researchers indicate that allo-SCT but not auto-SCT may salvage a subset of ATL patients, supporting the existence of graft vs ATL effect also in non-Japanese patients. [Bone Marrow Transplant] Abstract Non-Myeloablative Peripheral Blood Haploidentical Stem Cell Transplantation for Refractory Severe Aplastic Anemia Researchers report our pilot findings with haploidentical stem cell transplantation using uniform reduced intensity conditioning with post graft high dose cyclophosphamide in eight patients with refractory severe aplastic anemia or patients who rejected a prior unrelated donor or cord blood transplant. [Biol Blood Marrow Transplant] Abstract Allogeneic Hematopoietic Stem Cell Transplantation for Hematological Malignancies from Mismatched 9/10 HLA Unrelated Donors: Comparison with Transplantations from 10/10 Unrelated Donors and HLA Identical Siblings The authors retrospectively studied the outcome of 213 consecutive patients who received allo-HSCT for hematological malignancies, 121 from HLA identical siblings, 63 from 10/10 HLA identical unrelated donors and 29 from 9/10 HLA mismatched unrelated donors in their institution. [Leuk Lymphoma] Abstract |