Thrombopoietin Treatment of One Graft in a Double Cord Blood Transplant Provides Early Platelet Recovery while Contributing to Long Term Engraftment in NSG Mice Using a double cord blood (CB) murine transplant model, scientists investigated whether thrombopoietin cultured human CB CD34+ cells have a competitive advantage or disadvantage over untreated human CB CD34+ cells in terms of short and longer term platelet recovery and longer term hematological recovery. [Stem Cells Dev] Abstract Systemic Injection of CD34+ Enriched Human Cord Blood Cells Modulates Post-Stroke Neural and Glial Response in a Sex-Dependent Manner in CD1 Mice Investigators determined the impact of human cord blood derived CD34+-enriched mononuclear cells injected intraperitoneally on post-stroke neurogenic niche proliferation, glial response, and recovery in CD1 mice, when injected 48 hours after an ischemic insult at post-natal day 12. [Stem Cells Dev] Abstract Induction of Highly Functional Hepatocytes from Human Umbilical Cord Mesenchymal Stem Cells by HNF4α Transduction Researchers investigated the differentiation potential of human umbilical mesenchymal stem cells and the key factors that facilitate hepatic differentiation. [PLoS One] Full Article The Effect of Conditioned Medium Derived from Human Placental Multipotent Mesenchymal Stromal Cells on Neutrophils: Possible Implications for Placental Infection Scientists hypothesized that human placental multipotent mesenchymal stromal cells (hPMSCs) are involved in the early phases of bacterial infection. hPMSCs were isolated from term placentas and neutrophils from peripheral blood. [Mol Hum Reprod] Abstract Inner Ear Stem Cells Derived Feeder Layer Promote Directional Differentiation of Amniotic Fluid Stem Cells into Functional Neurons Scientists investigated the effect of inner ear stem cells derived feeder layer on amniotic fluid stem cells differentiation in vitro. An inner ear stem cells derived feeder layer direct contact system was established to induce differentiation of amniotic fluid stem cells. [Hear Res] Abstract The Effects of Gremlin1 on Human Umbilical Cord Blood Hematopoietic Progenitors Investigators examined the effects of Gremlin1 on long-term culture-initiating cells and transplantable hematopoietic stem cells in human umbilical cord blood. Gremlin1 inhibited BMP signaling, downregulated BMP-6 and cyclin E2 expression and upregulated hairy and enhancer of split-1 and Hedgehog interacting protein-1. [Blood Cells Mol Dis] Abstract Over-Expression of Oct4 and Sox2 Transcription Factors Enhances Differentiation of Human Umbilical Cord Blood Cells In Vivo Utilizing genetically modified human umbilical cord blood mono-nuclear cells, researchers report enhanced differentiation of transplants in a mouse model of amyotrophic lateral sclerosis. [Biochem Biophys Res Commun] Abstract Allogeneic Mesenchymal Stem Cell Transplantation for Lupus Nephritis Patients Refractory to Conventional Therapy In an open-label and single-center clinical trial, 81 Chinese patients with active and refractory lupus nephritis were enrolled. Allogeneic bone marrow- or umbilical cord-derived mesenchymal stem cells were administered intravenously at the dose of one million cells per kilogram of bodyweight. [Clin Rheumatol] Abstract Construction of Corneal Epithelium with Human Amniotic Epithelial Cells and Repair of Limbal Deficiency in Rabbit Models Investigators evaluated the effect of a human amniotic epithelial cell-rabbit corneal stroma tissue-engineered cornea on ocular reconstruction in three different animal models. [Hum Cell] Abstract |