Cord Blood News Volume 6.34 | Sep 4 2014

Umbilical Cord Mesenchymal Stem Cells Inhibit the Differentiation of Circulating T Follicular Helper Cells in Patients with Primary Sjögren’s Syndrome through the Secretion of Indoleamine
2,3-Dioxygenase
Scientists investigated the effect of umbilical cord mesenchymal stem cells (UC-MSCs) on circulating T follicular helper (cTfh) cells in primary Sjögren’s syndrome patients. In vitro, UC-MSCs suppressed the differentiation and proliferation of cTfh cells. [Rheumatology] Abstract

Treatment of Adult T-Cell Leukemia/Lymphoma with Cord Blood Transplantation: A Japanese Nationwide Retrospective Survey
To evaluate the role of cord blood transplantation (CBT) against adult T-cell leukemia/lymphoma (ATLL), investigators retrospectively analyzed data from 175 patients with ATLL who initially underwent single-unit CBT. [Biol Blood Marrow Transplant] Abstract

Human Bone Marrow, Umbilical Cord or Liver Mesenchymal Stromal Cells Fail to Improve Liver Function in a Model of CCl₄-Induced Liver Damage in NOD/SCID/IL-2Rγ(Null) Mice
Researchers examined the effect of mesenchymal stromal cell (bone marrow, umbilical cord and liver MSCs) intravenous injection on liver regeneration in a model of hepatic damage in NOD/SCID/IL non-obese diabetic/severe combined immunodeficient/interleukin-2Rγ(null) mice. [Cytotherapy] Abstract

Myeloablative Unrelated Cord Blood Transplantation for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Comparison with Other Graft Sources from Related and Unrelated Donors
Investigators retrospectively compared clinical outcomes after unrelated cord blood transplantation, unrelated bone marrow transplantation, and related bone marrow and peripheral blood stem cell transplantations following myeloablative conditioning in 40 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. [Ann Hematol] Abstract

Trisomy 21 Mid-Trimester Amniotic Fluid Induced Pluripotent Stem Cells Maintain Genetic Signatures during Reprogramming: Implications for Disease Modeling and Cryobanking
Researchers aimed to derive induced pluripotent stem cells from trisomy 21 human mid-trimester amniotic fluid stem cells and describe their hematopoietic and neurological characteristics. [Cell Reprogram] Abstract

miR-375 Induces Human Decidua Basalis-Derived Stromal Cells to Become Insulin-Producing Cells
miR-375 is a micro RNA that is expressed in the pancreas and involved in islet development. Human placental decidua basalis mesenchymal stem cells (PDB-MSCs) were cultured from full-term human placenta. The MSCs were chemically transfected with hsa-miR-375. [Cell Mol Biol Lett] Abstract

Mesenchymal Stem Cell-Based Angiotensin-Converting Enzyme 2 in Treatment of Acute Lung Injury Rat Induced by Bleomycin
After the isolation of human umbilical cord mesenchymal stem cells (HUMSCs) from cesarean fetus, scientists transfected the HUMSCs with angiotensin-converting enzyme 2 (ACE2) viral particles. They evaluated the therapeutic effect of HUMSCs harboring ACE2 on acute lung injury, which was induced by bleomycin in a rat model. [Exp Lung Res] Abstract

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AFL Approves Use of Regeneus’ Stem Cell Therapy, HiQCell for Injured Players
Regeneus Ltd. announced that the Australian Football League (AFL) has granted case-by-case approval for the use of its innovative stem cell therapy, HiQCell^® as a treatment option for injured AFL players, typically including impact related osteoarthritis and tendonitis. [Regeneus Ltd.] Press Release

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Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW Postdoctoral Fellow – Signaling in Hematopoiesis & Leukemia (Albert Einstein College of Medicine of Yeshiva University)

Research Assistant – Ex Vivo Cord Blood Expansion (MD Anderson Cancer Center)

Postdoctoral Positions – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Postdoctoral Positions – Hematologic Malignancies and Cellular Therapy (Duke University Department of Medicine)

Postdoctoral Fellowship – Developing Applications of Mesenchymal Stromal/Stem Cells in Hematopoietic Cell Transplantation (The Research Institute at Nationwide Children’s Hospital)

Postdoctoral Positions – Reprogramming and Genetic Engineering Technologies to Develop New Models of Hematopoiesis and Hematopoietic Disorders (Icahn School of Medicine)

Cord Tissue Processing Technician (Cord Blood Registry)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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