Melatonin Enhances the Human Mesenchymal Stem Cells Motility via Melatonin Receptor 2 Coupling with Gαq in Skin Wound Healing In a mouse skin excisional wound model, scientists found that transplantation of umbilical cord blood mesenchymal stem cells (UCB-MSCs) pre-treated with melatonin enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites, where relatively more UCB-MSCs which were engrafted onto the wound site were detected. [J Pineal Res] Abstract Paracrine Factors Secreted by Umbilical Cord Derived Mesenchymal Stem Cells Induce Angiogenesis In Vitro by a VEGF-Independent Pathway Researchers evaluated the presence of well-known pro-angiogenic factors in the conditioned media (CM) derived from umbilical cord derived-mesenchymal stem cells by ELISA. While VEGF was not detected in the CM, gene expression was nevertheless detected in these cells. [Stem Cells Dev] Abstract Mesenchymal Stromal Cells Derived from Blood Vessels or Avascular Tissues: What Is the Better Choice to Support Endothelial Cell Function? Investigators isolated and characterized mesenchymal stromal cells (MSC) from placental chorionic blood vessels and tested their angiogenic potential in comparison to amnion-derived avascular MSC. [Stem Cells Dev] Abstract Placental Mesenchymal Stem Cells of Fetal Origin Deposit Epigenetic Alterations during Long-Term Culture under Serum-Free Condition Fetal placental mesenchymal stem cells (fPMSCs) have shown promising cell therapy potential. However, their genetic and epigenetic stability during in vitro propagation has not been well studied. Investigators thus interrogated the methylation alterations and tumorigenicity of fPMSCs after in vitro expansion using serum-free medium. [Expert Opin Biol Ther] Abstract CD29 of Human Umbilical Cord Mesenchymal Stem Cells Is Required for Expansion of CD34+ Cells To investigate whether CD29 of human umbilical cord mesenchymal stem cells (hUCMSCs) would play a key role for the ability of hUCMSCs to expand hematopoietic stem cells, soluble anti-CD29 antibody was added to co-cultures of hUCMSCs and cord blood CD34+ cells. [Cell Prolif] Abstract Expanded Umbilical Cord Blood T Cells Used as Donor Lymphocyte Infusions after Umbilical Cord Blood Transplantation In vitro-cultured T cells from the umbilical cord blood (UCB) graft were explored as an alternative to conventional donor lymphocyte infusion (DLI). Scientists studied the safety of the cultured UCB T cells used as DLI because such cell preparations have not been used in this context previously. [Cytotherapy] Abstract Comparison of Umbilical Cord Blood Allogeneic Stem-Cell Transplantation (SCT) vs Auto-SCT for Adult Acute Myeloid Leukemia Patients in Second Complete Remission at Transplant: A Retrospective Study on Behalf of the SFGM-TC Investigators considered the outcomes of 181 acute myeloid leukemia patients transplanted in second complete remission who received either a myeloablative autologous SCT (auto-SCT) or an umbilical cord blood allogeneic SCT. [Eur J Haematol] Abstract Enhanced Human Mesenchymal Stem Cell Survival under Oxidative Stress by Overexpression of Secreted Frizzled-Related Protein 2 Gene Researchers investigated how to enhance the survival of human mesenchymal stem cells (hMSCs) under oxidative stress by overexpressing secreted frizzled-related protein 2 gene in bone marrow-derived hMSCs and umbilical cord-derived hMSCs. [Ann Hematol] Abstract The Functional Study of Human Umbilical Cord Mesenchymal Stem Cells Harboring Angiotensin-Converting Enzyme 2 in Rat Acute Lung Ischemia-Reperfusion Injury Model The authors aimed to find a more effective therapeutic approach to treat acute lung ischemia-reperfusion injury (ALIRI). They evaluated the combinational effects of human umbilical cord mesenchymal stem cells and angiotensin-converting enzyme 2 in the rat ALIRI model. [Cell Biochem Funct] Abstract |