Identification and Clinical Relevance of Naturally Occurring Human CD8+HLA-DR+ Regulatory T Cells Scientists show that CD8+ T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8+ regulatory T cell subset. [J Immunol] Abstract Human CD133-Positive Hematopoietic Progenitor Cells Initiate Growth and Metastasis of Colorectal Cancer Cells CD133+ human hematopoietic progenitor cells (HUHPCs) were purified from human umbilical cord blood and expanded in vitro. Scientists studied the effects of CD133+ HUHPCs on the growth and metastasis of four colorectal cancer cell lines by using cell-to-cell co-culture. [Carcinogenesis] Abstract Role of Gamma-Secretase in Human Umbilical-Cord Derived Mesenchymal Stem Cell Mediated Suppression of NK Cell Cytotoxicity Umbilical cord derived mesenchymal stem cells could potently suppress natural killer (NK) cell cytotoxicity in overnight cultures via soluble factors. The main soluble immunosuppressant was identified as prostaglandin-E2. [Cell Commun Signal] Abstract | Full Article Diet Composition Transiently Modulates Proliferative and Potency Features of Human Cord Blood-Derived Mesenchymal Stem Cells Scientists compared the effects during culture of two different mesenchymal stem cell (MSC) commercial media on the proliferative capacities, phenotypic and molecular features in human cord blood derived-MSC lines. [Int J Biochem Cell Biol] Abstract S100A6 Is Secreted from Wharton’s Jelly Mesenchymal Stem Cells and Interacts with Integrin β1 Using mesenchymal stem cells isolated from Wharton’s jelly of the umbilical cord, researchers showed that S100A6 is secreted by these cells, and when added to the medium, increases their adhesion and inhibits proliferation. [Int J Biochem Cell Biol] Abstract Bone Marrow Stromal Cells Transduced with a Thrombopoietin, Interleukin-6, and Interleukin-11 Syncretic Gene Induce Cord Mononuclear Cells to Generate Platelets In Vitro The thrombopoietin, interleukin (IL)-6, and IL-11 genes, three regulatory factors important for thrombopoiesis, were used to construct self-splicing fusion genes linked by foot and mouth disease and Theiler’s murine encephalitis viruses. Bone marrow stromal cells transduced with the fusion gene acted as nourishing cells and induced cord blood mononuclear cells to generate platelets in vitro. [Transfusion] Abstract Impact of Long Term Cryopreservation on Single Umbilical Cord Blood Transplant Outcomes The authors sought to determine the effect of umbilical cord blood (UCB) unit cryopreservation time on hematopoietic potency. They analyzed 288 single UCB units used for transplantation. [Biol Blood Marrow Transplant] Abstract Amniotic Fluid-Derived Stem Cells Demonstrated Cardiogenic Potential in Indirect Co-Culture with Human Cardiac Cells Investigators examined human amniotic fluid-derived stem cell cardiogenic potential in indirect co-culture with human cardiac cells in conditions that eliminated the possibility of cell fusion. [Ann Biomed Eng] Abstract Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Myelodysplastic Syndromes: A Multicenter Experience from Argentina A retrospective analysis of 54 allogeneic hematopoietic stem cell transplantations was carried out in 52 patients. Donors were related in 32 cases and the stem cells sources were: bone marrow, peripheral blood, and umbilical cord blood. [Pediatr Blood Cancer] Abstract Early Umbilical Cord Blood-Derived Stem Cell Transplantation Does Not Prevent Neurological Deterioration in Mucopolysaccharidosis Type III Researchers report on the five-year outcome of early transplantation, i.e., before onset of clinical neurological disease, in combination with the use of umbilical cord blood-derived hematopoietic stem cells, in two mucopolysaccharidosis type III patients. [JIMD Rep] Abstract |