Cord Blood News Volume 7.02 | Jan 22 2015

Immune Reconstitution/Immunocompetence in Recipients of Kidney plus Hematopoietic Stem/Facilitating Cell Transplants
Researchers prospectively evaluated immune reconstitution and immunocompetence. Return of CD4 and CD8 T central and effector memory cell populations was rapid. T-cell receptor Excision Circle analysis showed a significant proportion of chimeric cells produced were being produced de novo. [Transplantation] Abstract

Allogeneic Stem Cell Transplantation for Refractory Acute Myeloid Leukemia: A Single Center Analysis of Long-Term Outcome
Investigators analyzed the long-term outcome of 131 consecutive patients with active acute myeloid leukemia, which was either primary refractory or unresponsive to salvage chemotherapy. [Eur J Haematol] Abstract

Onset of Ocular Graft-versus-Host Disease Symptoms after Allogeneic Hematopoietic Stem Cell Transplantation
Researchers studied the factors affecting the time to onset of ocular graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation. [Cornea] Abstract

Outcomes of Peripheral Blood Stem Cell Transplantation Patients from HLA-Mismatched Unrelated Donor with Antithymocyte Globulin (ATG)-Thymoglobulin versus ATG-Fresenius: A Single-Center Study
Retrospective analysis of patients who underwent HLA-mismatched peripheral blood stem cell transplantation from unrelated donors and received pre-transplant ATG-Thymoglobulin at a total dose of 10 mg/kg or ATG-Fresenius at a total dose of 20 mg/kg was performed. [Med Oncol] Abstract

Lentiviral-Mediated Overexpression of Homeobox A4 by Human Umbilical Cord Mesenchymal Stem Cells Repairs Full-Thickness Skin Defects
The effect of homeobox A4 (HOXA4) overexpression by human umbilical cord mesenchymal stem cells (hUMSCs) on fullthickness skin repair was evaluated. Isolated hUMSCs were transfected with a lentivirus expressing HOXA4 and cultured for 21 days. [Mol Med Rep] Abstract

Human Umbilical Cord and Dental Pulp-Derived Mesenchymal Stem Cells: Biological Characteristics and Potential Roles In Vitro and In Vivo
The differentiation, survivin modified effects and molecular basis of human umbilical cord derived mesenchymal stem/stromal cells and dental pulp derived stem cells were investigated. [Mol Med Rep]
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Bellicum Pharmaceuticals Announces Successful Dosing of First Patient Cohort with BPX-501 T Cells Following Haplo-Identical Hematopoietic Stem Cell Transplant
Bellicum Pharmaceuticals, Inc. announced that the first cohort of patients in the BP-004 trial has completed dosing with the company’s genetically engineered donor T cells (BPX-501) after receiving a partial T depleted haplo-identical allogeneic hematopoietic stem cell transplant. [Bellicum Pharmaceuticals, Inc.] Press Release

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NEW Postdoctoral Researcher – Umbilical Cord Derived HSCs and MSCs (University of Crete)

Principal Investigator – Stem Cell Biology, Hematopoiesis and Hematology (Guangzhou Women and Children’s Medical Center)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Postdoctoral Position – Hematopoietic Gene Regulation and Leukemia (Boston Children’s Hospital)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Cord Tissue Processing Technician (Cord Blood Registry)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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